Quick Order

HER2 / ErbB2 Antibody, Rabbit PAb

    DatasheetReviewsRelated ProductsProtocols
    Mouse ERBB2 Antibody Product Information
    Immunogen:Recombinant Mouse HER2 / ErbB2 protein (Catalog#50714-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse HER2 / ErbB2 (rM HER2 / ErbB2; Catalog#50714-M08H; P70424; Met1-Thr653). Total IgG was purified by Protein A affinity chromatography.
    Other ERBB2 Antibody Products
    HER2/ERBB2 Background

    Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Mouse HER2/ERBB2 References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Product nameProduct name
    Size / Price
    Catalog: 50714-RP01-400
    List Price: 
    Price:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"