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HER2 / ErbB2 / CD340 Antibody, Rabbit PAb

  • HER2 / ErbB2 Antibody, Rabbit PAb, Western blot
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Human ErbB2/HER2 Antibody Product Information
Immunogen:Recombinant Human ErbB2 protein (Catalog#10004-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human ErbB2 / HER2 extracellular domain (rhErbB2; Catalog#10004-H08H; NP_004439.2; Met 1-Thr652). Total IgG was purified by Protein A affinity chromatography.
Human ErbB2/HER2 Antibody WB Application Image
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HER2/ERBB2 Background

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human HER2/ERBB2 References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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    Catalog: 10004-RP03-400
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    Datasheet & Documentation

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"