Anti-Her2 / ERBB2 Antibody

Cat: 10004-RP03
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Anti-Her2 / ERBB2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Her2 / ERBB2 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human Her2 / ERBB2
Immunogen
Recombinant Human ErbB2 protein (Catalog#10004-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ErbB2 / HER2 extracellular domain (rhErbB2; Catalog#10004-H08H; NP_004439.2; Met 1-Thr652). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Her2 / ERBB2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Her2 / ERBB2 Antibody (Rabbit Polyclonal antibody) Images
Human HER2/ERBB2 Western blot (WB) 13031

Anti-ERBB2 rabbit polyclonal antibody at 1:500 dilution

Lane A: SKBR3 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:195 kDa

Observed band size:195 kDa

Anti-Her2 / ERBB2 Antibody Alternative Names
Anti-CD340 Antibody;Anti-HER-2 Antibody;Anti-HER-2/neu Antibody;Anti-HER2 Antibody;Anti-MLN 19 Antibody;Anti-MLN19 Antibody;Anti-NEU Antibody;Anti-NGL Antibody;Anti-TKR1 Antibody
Her2 / ERBB2 Background Information

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 2
References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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