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HBEGF Protein

Heparin-binding EGF-like growth factor

HBEGF Products

HBEGF Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
HBEGF Human HBEGF Protein, Recombinant, Native 10325-HNAB

HBEGF Cell Lysates

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
HBEGF Human Human HBEGF / DTR Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) 10325-HNABL

HBEGF cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
HBEGF Human Human HBEGF cDNA Clone / ORF Clone HG10325-M
HBEGF Mouse Mouse HBEGF cDNA Clone / ORF Clone MG50172-M

HBEGF Related Areas

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>HBEGF

HBEGF Alternative Names

HBEGF, DTR, DTS, DTSF, HEGFL [Homo sapiens]

Hbegf, AW047313, Dtr, Dts, Hegfl, MGC107656 [Mus musculus]

HBEGF Background

Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4 and binds to cell surface HSPG. The transmembrane form of HBEGF is a juxtacrine growth and adhesion factor and is uniquely the receptor for diphtheria toxin. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HBEGF participates in diverse biological processes, including heart development and maintenance, skin wound healing, eyelid formation, blastocyst implantation, progression of atherosclerosis and tumor formation, through the activation of signaling molecules downstream of ErbB receptors and interactions with molecules associated with HBEGF. tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta markedly increased HB-EGF mRNA levels in HUVEC by 12- and 7-fold, respectively, and induction of the gene by TNF-alpha was both dose- and time-dependent.

HBEGF Related Studies

  1. Miyamoto S, et al. (2006) Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci. 97(5): 341-7.
  2. Raab G, et al. (1997) Heparin-binding EGF-like growth factor. Biochim Biophys Acta. 1333(3): 179-99.
  3. Pathak BG, et al. (1995) Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). Genomics. 28(1): 116-8.

 

HBEGF related areas, pathways, and other information

 

Related Information

EGFR (ErbB1, HER1)

ErbB2 (HER2)

ErbB3 (HER3)

ErbB4 (HER4)

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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