HAPLN1 Protein (CRTL1 Protein)

Hyaluronan And Proteoglycan Link Protein 1 (Cartilage Linking Protein 1)

HAPLN1 Products

HAPLN1 Protein, Recombinant

Molecule	Species	Description	Cat. No
HAPLN1/CRTL1	Human	HAPLN1 Protein, Recombinant	10323-H08H

HAPLN1 cDNA Clone

Molecule	Species	Description	Cat. No
HAPLN1/CRTL1	Human	Homo sapiens HAPLN1 cDNA Clone(NM_001884.3)	HG10323-M

HAPLN1 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Hyaluronic Acid Binding Protein>>HAPLN1/CRTL1

HAPLN1 Alternative Names

HAPLN1, CRTL1 [Homo sapiens]

Hapln1, Crtl1, Crtl1l, BB099155, CLP, LP [Mus musculus]

HAPLN1 Background

Hyaluronan (HA) is a high MW glycosaminoglycan significantly involved in the formation and stability of extracellular matrix via its association with specific HA-binding proteins. HAPLN1, also known as CRTL1 (Cartilage Link Protein 1, cLP ) and link protein, is a member of HA-binding protein (hyaladherins) family, and contains a common structural domain of about 100 amino acids that is termed a Link module with two α-helices and two antiparallel β-sheets. HAPLN1/CRTL1 stabilizes the interaction between hyaluronan (HA) and versican, two extracellular matrix components essential for cardiac development. Link module superfamily can be divided into three subgroups, and the HAPLN family are C domain-type proteins that have an extended structure with one N-terminal V-type Ig-like domain followed by two link modules. In cartilage, aggrecan forms - cLP stabilized aggregates with HA that provides the tissue with its load bearing properties. HAPLN1 is a component of follicular matrix, was shown to enhance cumulus-oocyte complex (COC) expansion in vitro. HAPLN1 may promote periovulatory granulosa cell survival, which would facilitate their differentiation into luteal cells.

HAPLN1 Related Studies

1. Sun GW, et al. (2003) Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells. Endocrinology. 144(3): 793-801.
2. Wirrig EE, et al. (2007) Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol. 310(2): 291-303.
3. Liu J, et al. (2010) Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function. Mol Endocrinol. 24(6): 1203-17.