Anti-HAO1 Antibody

Cat: 12076-R001
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Anti-HAO1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-HAO1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human HAO1
Immunogen
Recombinant Human HAO1 / GOX1 protein (Catalog#12076-H07E)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human HAO1 (rh HAO1; Catalog#12076-H07E; NP_060015.1; Leu 2-Ile 370).
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HAO1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HAO1 Antibody Alternative Names
Anti-GOX Antibody;Anti-GOX1 Antibody;Anti-HAOX1 Antibody
HAO1 Background Information

Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1 and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 / GOX1 is a peroxisomal protein and that the C-terminal sequence SKI acts as the targeting signal. Down-regulation of HAO1 / GOX1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to oxidative injury involving down-regulation of ROS-producing enzymes.

Full Name
hydroxyacid oxidase (glycolate oxidase) 1
References
  • Jones J.M.et al., 2000, J. Biol. Chem. 275:12590-7.
  • Recalcati,S. et al., 2001, J Cell Sci. 114 (Pt 9):1625-9.
  • Recalcati,S. et al., 2003, Hepatology. 38 (5):1159-66.
  • Murray M.S.et al., 2008, Biochemistry 47:2439-49.
  • Bourhis J.M.et al., 2009, Acta Crystallogr. F 65:1246-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HAO1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 12076-T56
    Anti-HAO1 Antibody Rabbit Polyclonal ELISA 12076-RP01
    Anti-HAO1 Antibody Rabbit Polyclonal ELISA 12076-RP02
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