Anti-HAO1 Antibody

Cat: 12076-R001
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Anti-HAO1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-HAO1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human HAO1
Recombinant Human HAO1 / GOX1 protein (Catalog#12076-H07E)
This antibody was obtained from a rabbit immunized with purified, recombinant Human HAO1 (rh HAO1; Catalog#12076-H07E; NP_060015.1; Leu 2-Ile 370).
Monoclonal Rabbit IgG Clone #001
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HAO1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HAO1 Antibody Alternative Names
Anti-GOX Antibody;Anti-GOX1 Antibody;Anti-HAOX1 Antibody
HAO1 Background Information

Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1 and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 / GOX1 is a peroxisomal protein and that the C-terminal sequence SKI acts as the targeting signal. Down-regulation of HAO1 / GOX1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to oxidative injury involving down-regulation of ROS-producing enzymes.

Full Name
hydroxyacid oxidase (glycolate oxidase) 1
  • Jones al., 2000, J. Biol. Chem. 275:12590-7.
  • Recalcati,S. et al., 2001, J Cell Sci. 114 (Pt 9):1625-9.
  • Recalcati,S. et al., 2003, Hepatology. 38 (5):1159-66.
  • Murray al., 2008, Biochemistry 47:2439-49.
  • Bourhis al., 2009, Acta Crystallogr. F 65:1246-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HAO1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 12076-T56
    Anti-HAO1 Antibody Rabbit Polyclonal ELISA 12076-RP01
    Anti-HAO1 Antibody Rabbit Polyclonal ELISA 12076-RP02
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