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HAGH / GLO2 / Glyoxalase II Protein & Antibody

Hydroxyacylglutathione hydrolase

HAGH / GLO2 / Glyoxalase II Products

HAGH / GLO2 / Glyoxalase II Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
HAGH/GLO2 Human HAGH/GLO2/Glyoxalase II Protein, Recombinant 12146-H08E

HAGH / GLO2 / Glyoxalase II Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human HAGH/GLO2 WB, ELISA HAGH / GLO2 / Glyoxalase II Antibody 12146-RP01
Human HAGH/GLO2 ELISA, IHC-P HAGH / GLO2 / Glyoxalase II Antibody (Antigen Affinity Purified) 12146-RP02

HAGH / GLO2 / Glyoxalase II Related Areas

Enzyme>>Other>>HAGH/GLO2/Glyoxalase II

HAGH / GLO2 / Glyoxalase II Alternative Names

HAGH, GLO2, Glyoxalase II, GLX2, GLXII, HAGH1 [Homo sapiens]

HAGH, Glo2, Glyoxalase II, BC019817, Glo-2, Rsp29 [Mus musculus]

HAGH / GLO2 / Glyoxalase II Background

Glyoxalase II(HAGH/GLO2), also named Hydroxyacylglutathione hydrolase, belongs to the glyoxalase system and is classified as a thiolesterase. The glyoxalase system contains both glyoxalase I and glyoxalase II which has been found widely distributed in animal tissues, plants, and microorganisms. Both glyoxalase I and glyoxalase II step in the detoxification of methylglyoxal. There are two separable enzymatic steps in the conversion of methylglyoxal to lactic acid in animal tissues. The first step consists in a condensation reaction between methylglyoxal and glutathion into S-2-hydroxyacylglutathione catalyzed by glyoxalase I. This condensation product, in a second step which is catalyzed by glyoxalase II, is then broken down into glutathione and lactic acid.In the mitobolism progression, reduced glutathione was required for the action of glyoxalase . The existence of a protein factor which accelerated lactic acid formation from methylglyoxal in the presence of partially purified glyoxalase also required.

HAGH / GLO2 / Glyoxalase II Related Studies

  1. Mulley JC, et al. (1987). New regional localisations for HAGH and PGP on human chromosome 16. Hum Genet 74 (4): 423–4.
  2. Rulli A, et al. (2001). Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res. Treat. 66 (1): 67–72.
  3. Cordell PA, et al. (2004). The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 279 (27): 28653–61.

 

Hydroxyacylglutathione Hydrolase (GLO2) related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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