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>HAGH / GLO2 / Glyoxalase II Protein & Antibody
HAGH / GLO2 / Glyoxalase II Protein & Antibody
HAGH / GLO2 / Glyoxalase II Products
HAGH / GLO2 / Glyoxalase II Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|HAGH/GLO2||Human||HAGH/GLO2/Glyoxalase II Protein, Recombinant||12146-H08E|
HAGH / GLO2 / Glyoxalase II Antibody
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human HAGH/GLO2||WB, ELISA||HAGH / GLO2 / Glyoxalase II Antibody||12146-RP01|
|Human HAGH/GLO2||ELISA, IHC-P||HAGH / GLO2 / Glyoxalase II Antibody (Antigen Affinity Purified)||12146-RP02|
HAGH / GLO2 / Glyoxalase II Related Areas
HAGH / GLO2 / Glyoxalase II Alternative Names
HAGH, GLO2, Glyoxalase II, GLX2, GLXII, HAGH1 [Homo sapiens]
HAGH, Glo2, Glyoxalase II, BC019817, Glo-2, Rsp29 [Mus musculus]
HAGH / GLO2 / Glyoxalase II Background
Glyoxalase II(HAGH/GLO2), also named Hydroxyacylglutathione hydrolase, belongs to the glyoxalase system and is classified as a thiolesterase. The glyoxalase system contains both glyoxalase I and glyoxalase II which has been found widely distributed in animal tissues, plants, and microorganisms. Both glyoxalase I and glyoxalase II step in the detoxification of methylglyoxal. There are two separable enzymatic steps in the conversion of methylglyoxal to lactic acid in animal tissues. The first step consists in a condensation reaction between methylglyoxal and glutathion into S-2-hydroxyacylglutathione catalyzed by glyoxalase I. This condensation product, in a second step which is catalyzed by glyoxalase II, is then broken down into glutathione and lactic acid.In the mitobolism progression, reduced glutathione was required for the action of glyoxalase . The existence of a protein factor which accelerated lactic acid formation from methylglyoxal in the presence of partially purified glyoxalase also required.
HAGH / GLO2 / Glyoxalase II Related Studies
- Mulley JC, et al. (1987). New regional localisations for HAGH and PGP on human chromosome 16. Hum Genet 74 (4): 423–4.
- Rulli A, et al. (2001). Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res. Treat. 66 (1): 67–72.
- Cordell PA, et al. (2004). The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 279 (27): 28653–61.