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HAGH Protein, Antibody, ELISA Kit, cDNA Clone

HAGH Related Areas

HAGH Related Pathways

HAGH Related Product

    HAGH Summary & Protein Information

    HAGH Background

    Gene Summary: The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    Catalytic activity: S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.
    Cofactor: Binds 2 zinc ions per subunit.
    Subunit structure: Monomer.
    Domain: The CRAL-TRIO domain is known to bind small hydrophobic molecules (By similarity).
    Subcellular location: Isoform 1: Mitochondrion matrix.
    Isoform 2: Cytoplasm.
    Tissue specificity: Expressed in liver and kidney.
    Post-translational: Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2.
    May be ubiquitinated by STUB1.
    Involvement in disease: Cerebellar ataxia, cayman type (ATCAY) [MIM:601238]: Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
    General information above from UniProt

    HAGH Alternative Name

    HAGH Related Studies

  • Mulley JC, et al. (1987). New regional localisations for HAGH and PGP on human chromosome 16. Hum Genet 74 (4): 423-4.
  • Rulli A, et al. (2001). Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res. Treat. 66 (1): 67-72.
  • Cordell PA, et al. (2004). The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 279 (27): 28653-61.
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