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Influenza Hemagglutinin (HAAntibody

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Influenza  Hemagglutinin (HAAntibody Products

H1N1A/Brevig Mission/1/1918

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB,IP11055-MM04-50
11055-MM04-100
11055-MM04-1
50 µg/
100 µg/
1 mg/
Add to Cart
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF11068-RP01-200
11068-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,IP11068-T60-100
11068-T60-50
100 µg/
50 µg/
Add to Cart
Add to Cart

H1N1A/Brisbane/59/2007

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB,IP11052-MM06-50
11052-MM06-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM,IP11055-MM09-50
11055-MM09-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H1N1A/California/04/2009

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,IHC-P,IF,ICC/IF11055-MM01-50
11055-MM01-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB11055-RM05-50
11055-RM05-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbWB,IP11055-RM10-50
11055-RM10-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IP11055-RP01-200
11055-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbWB11055-RP02-100
11055-RP02-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA HRP Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB11055-RP07-50
11055-RP07-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,IHC-P11055-T24-50
11055-T24-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbWB,IHC-P,IP11055-T44-50
11055-T44-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,IP11055-T60-50
11055-T60-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H1N1A/Puerto Rico/8/1934

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB11684-MM03-50
11684-MM03-100
11684-MM03-1
50 µg/
100 µg/
1 mg/
Add to Cart
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB,FCM,IF,ICC/IF11684-R107-50
11684-R107-100
11684-R107-1
50 µg/
100 µg/
1 mg/
Add to Cart
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,WB11684-RP01-100
11684-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11684-RP02-50
11684-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,IHC-P11684-T24-50
11684-T24-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P11684-T56-50
11684-T56-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H1N2A/swine/Guangxi/13/2006

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11703-RP01-100
11703-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11703-RP02-50
11703-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H1N3A/duck/NZL/160/1976

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB,IP11685-MM03-50
11685-MM03-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,IF,ICC/IF11685-MM07-50
11685-MM07-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,WB11685-RP01-100
11685-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11685-RP02-50
11685-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H2N2A/Canada/720/2005

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11688-RP01-100
11688-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11688-RP02-50
11688-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,IF11714-MM05-1
11714-MM05-50
11714-MM05-100
1 mg/
50 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart

H3N2A/Brisbane/10/2007

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,B/N11055-MM11-50
11055-MM11-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM,IF,IP,ICC/IF11056-MM03-50
11056-MM03-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM,IP,HI11056-MM05-50
11056-MM05-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,FCM,IF,ICC/IF11056-R006-100
11056-R006-50
100 µg/
50 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,FCM,IF,ICC/IF11056-R104-100
11056-R104-50
100 µg/
50 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,WB11056-RP01-100
11056-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11056-RP02-50
11056-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H4N6A/mallard/Ohio/657/2002

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11714-RP01-100
11714-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11714-RP02-50
11714-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H5N1A/Anhui/1/2005

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB,B/N11048-MM01-50
11048-MM01-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB11048-MM03-50
11048-MM03-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB11048-MM04-50
11048-MM04-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbWB,IHC-P,FCM,IF,IP,ICC/IF11048-MM05-50
11048-MM05-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA11048-MM06-50
11048-MM06-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM,IP11048-MM10-50
11048-MM10-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM,IP11048-MM11-50
11048-MM11-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB,FCM11048-RM07-50
11048-RM07-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB,FCM11048-RM08-50
11048-RM08-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB11048-RM09-50
11048-RM09-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbWB11048-RP02-100
11048-RP02-200
11048-RP02-50
100 µg/
200 µg/
50 µL/
Add to Cart
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,WB,FCM11055-MM08-50
11055-MM08-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB11055-RM06-50
11055-RM06-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB86001-RM01-50
86001-RM01-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB,IHC-P,FCM,IF,IP,ICC/IF86001-RM02-50
86001-RM02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H5N2A/American green-winged teal/California/HKWF609/07

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11699-RP01-100
11699-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11699-RP02-50
11699-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H5N3A/duck/Hokkaido/167/2007

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11696-RP01-100
11696-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11696-RP02-50
11696-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H5N8A/duck/NY/191255-59/2002

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11717-RP01-100
11717-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11717-RP02-50
11717-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H6N1A/northern shoveler/California/HKWF115/2007

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB,IP11723-MM04-50
11723-MM04-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF11723-RP01-200
11723-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,IP11723-T60-50
11723-T60-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H7N7A/chicken/Netherlands/1/03

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit MAbRabbitMAbELISA,HI11082-R019-500
11082-R019-200
500 µg/
200 µg/
Add to Cart
Add to Cart

H7N7A/Netherlands/219/2003

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,IHC-P11082-T24-100
11082-T24-50
100 µg/
50 µg/
Add to Cart
Add to Cart

H7N9A/Anhui/1/2013

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,WB11082-MM04-50
11082-MM04-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,FCM,MN,HI,B/N11082-R002-1
11082-R002-50
11082-R002-100
1 mg/
50 µg/
100 µg/
Add to Cart
Add to Cart
Add to Cart
HA FITC Rabbit MAbRabbitMAbFCM11082-R002-F-100
11082-R002-F-25
100 Tests/
25 Test/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,FCM11082-R011-50
11082-R011-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,FCM,IF,ICC/IF40103-MM06-100
40103-MM06-50
100 µg/
50 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF40103-RP01-200
40103-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP40103-RP02-50
40103-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H7N9A/Shanghai/1/2013

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF40104-RP01-200
40104-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP40104-RP02-50
40104-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H8N4A/pintail duck/Alberta/114/1979

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbELISA,IF,ICC/IF11722-MM07-50
11722-MM07-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbWB,IP11722-MM08-100
11722-MM08-50
100 µg/
50 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,WB11722-RP01-100
11722-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11722-RP02-50
11722-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H9N2A/Hong Kong/1073/99

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbWB,IHC-P,FCM,IF,IP,ICC/IF11229-MM04-50
11229-MM04-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,FCM11229-MM09-50
11229-MM09-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB,FCM11229-R106-50
11229-R106-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,WB11229-RP01-100
11229-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11229-RP02-50
11229-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H10N3A/duck/Hong Kong/786/1979

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11693-RP01-100
11693-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11693-RP02-50
11693-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H10N8A/Jiangxi-Donghu/346/2013

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbMN,HI40359-M001-500
40359-M001-200
500 µg/
200 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMN,HI40359-mh001-500
40359-mh001-200
500 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,FCM,IF,ICC/IF40359-R137-50
40359-R137-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H11N2A/duck/Yangzhou/906/2002

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11705-RP01-100
11705-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11705-RP02-50
11705-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H11N9A/mallard/Alberta/294/1977

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11704-RP01-100
11704-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11704-RP02-50
11704-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H12N5A/green-winged teal/ALB/199/1991

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11718-RP01-100
11718-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11718-RP02-50
11718-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H13N8A/black-headed gull/Netherlands/1/00

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11721-RP01-100
11721-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11721-RP02-50
11721-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H15N8A/duck/AUS/341/1983

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF11720-RP01-200
11720-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,IP11720-T60-50
11720-T60-100
50 µg/
100 µg/
Add to Cart
Add to Cart

H16N3A/black-headed gull/Sweden/5/99

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,WB11711-RP01-100
11711-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,WB,IHC-P,FCM,IP11711-RP02-50
11711-RP02-100
50 µg/
100 µg/
Add to Cart
Add to Cart

Influenza BB/Florida/4/2006

ProductHostCloneApplicationCat No.Package/Price 
HA Mouse MAbMouseMAbWB,IP11053-MM06-50
11053-MM06-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Mouse MAbMouseMAbELISA,IHC-P,IF11053-MM09-50
11053-MM09-100
11053-MM09-1
50 µg/
100 µg/
1 mg/
Add to Cart
Add to Cart
Add to Cart
HA Rabbit MAbRabbitMAbELISA,WB11053-R004-50
11053-R004-100
50 µg/
100 µg/
Add to Cart
Add to Cart
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF11053-RP01-100
11053-RP01-200
100 µg/
200 µg/
Add to Cart
Add to Cart
HA Rabbit PAb , Antigen Affinity PurifiedRabbitPAbELISA,IHC-P11053-T24-100
11053-T24-50
100 µg/
50 µg/
Add to Cart
Add to Cart

Influenza BB/Massachusetts/03/2010

ProductHostCloneApplicationCat No.Package/Price 
HA Rabbit PAbRabbitPAbELISA,IHC-P,FCM,IF,IP,ICC/IF40191-RP01-200
40191-RP01-100
200 µg/
100 µg/
Add to Cart
Add to Cart

Additional Influenza Hemagglutinin (HA) Products

Influenza Hemagglutinin (HA) Background

Influenza (flu) is a respiratory infection in mammals and birds. It is caused by an RNA virus in the family Orthomyxoviridae. The virus is divided into three main types (Influenza A, Influenza B, and Influenza C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA)). Influenza virus type A is found in a wide variety of bird and mammal species and can undergo major shifts in immunological properties. Influenza B is largely confined to humans and is an important cause of morbidity. Little is known about Influenza C, which is not an important source of morbidity.

Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The notation HhNn is used to refer to the subtype comprising the hth discovered Hemagglutinin (HA) protein and the nth discovered neuraminidase (NA) protein. Influenza viruses that are known to infect human include the following sub-types. H1N1 virus that caused "Spanish Flu" (A/BrevigMission/1/1918(H1N1)) and seasonal flu (A/Brisbane/59/2007(H1N1), A/New Caledonia/20/1999(H1N1), and A/Solomon Islands/3/2006 (H1N1)) and a reassorted virus (A/California/04/2009(H1N1)) that caused the 2009 swine flu outbreak; H2N2 virus that caused the "Asian Flu"; H3N2 virus that caused the "Hong Kong Flu"; H5N1 "The Bird Flu" virus (A/Anhui/1/2005 (H5N1), A/Vietnam/1203/2004, A/Vietnam/1194/2004 (H5N1), A/bar-headed goose/Qinghai/14/2008 (H5N1), A/turkey/1/2005 (H5N1), A/Indonesia/5/2005 (H5N1)) that was the world's major influenza pandemic threat until the Swine Flu Pandemic of 2009; H7N7 virus that has unusual zoonotic potential; H1N2 is currently endemic in humans and pigs; and H9N2, H7N2, H7N3, H10N7 viruses.

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer, and the influenza viral neuraminidase (NA) protein is a tetramer with an enzyme active site on the head of each monomer. Subtypes are further divided into strains; each genetically distinct virus isolate is usually considered to be a separate strain.

The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA0, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA0) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.

The influenza virus neuraminidase (NA) protein is a second major surface antigen of the virion. Neuraminidase (NA) cleaves terminal sialic acid from glycoproteins or glycolipids. Thus, it functions to free virus particles from host cell receptors, to permit progeny virions to escape from the cell in which they arose, and so facilitate virus spread.

On April 29th 2009, the World Health Organization (WHO) announced that the rapid global spread of a new swine origin strain of influenza A (H1N1) virus (A/California/04/2009 (H1N1), A/California/06/2009 (H1N1), A/California/07/2009 (H1N1)) detected in the previous week warranted moving the global flu pandemic alert level to phase 5. Phase 5 indicates sustained human-to-human transmission of a novel influenza strain of animal origin in one WHO region of the world, and exported cases detected in other regions. Since its outbreak, the new swine influenza H1N1 virus has infected millions of people worldwide and hundreds of death. This new influenza outbreak is commonly referred to as the 2009 swine flu pandemic.

The highly pathogenic H5N1 avian influenza virus has become endemic in poultry in southeast Asia since 2003 and constitutes a major pandemic threat to humans. During 2004, H5N1 virus caused poultry disease in eight Asian countries and infected at least 44 persons, killing 32; most of these persons had had close contact with poultry.

Influenza virus vaccination is an effective approach to control influenza virus infection and pandemic spread of the virus. Each seasonal influenza vaccine contains hemagglutinin (HA) and neuraminidase antigen from three influenza subtype viruses-one subtype Influenza A H3N2 virus, one regular seasonal Influenza A H1N1 virus (not the 2009 H1N1 virus), and one Influenza B virus. Because of the influenza virus continues to mutate (antigen minor drifting or antigen major shifting) over time, the viruses in the vaccine change each year based on international surveillance and scientists' estimations about which types and strains of viruses will circulate in a given year. About 2 weeks after vaccination of the influenza viral antigen, antibodies that provide protection against influenza virus infection develop in the body.

Seasonal influenza virus vaccines are manufactured with a 50-year old egg-based process technology. Virus seed is injected into fertilized chicken eggs and incubated for several days to allow the virus to replicate and accumulate in the fluid surrounding the embryo. The virus fluid is collected from the inoculated eggs and harvested, purified, chemically inactivated and used to produce the vaccine.

Protection mechanism of influenza vaccine is well established to be neutralizing antibody (polyclonal human antibody) raised against influenza viral protein antigen such as the hemagglutinin (HA ) and neuraminidase (NA) protein antigen. Neutralizing antibody can block virus binding to host cells, block viral entry into host cells, and kill infected host cells. Recombinant monoclonal antibody (Mab, mouse monoclonal antibody, rabbit monoclonal antibody, chimeric monoclonal antibody, humanized monoclonal antibody) raised against the hemagglutinin (HA ) antigen or cloned from human B-cells (human monoclonal antibody) have shown to be promising anti-influenza infection product candidates.

Monoclonal or polyclonal antibody can be raised with peptide based antigen or protein based antigen. Antibody raised with protein based antigen could have better specificity and/or binding affinity than antibody raised with peptide based antigen, but cost associated with the recombinant protein antigen is usually higher. Anti influenza virus hemagglutinin (HA) monoclonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohistochemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection.

Sino Biological is committed to use its expertise in recombinant protein and antibody development to provide solutions to support the influenza research community worldwide. Our solutions include contract service, recombinant hemagglutinin (HA) protein reagent, mouse and rabbit anti-hemagglutinin (HA) monoclonal antibody, anti-hemagglutinin (HA) polyclonal antibody, H1N1 hemagglutinin (HA) antibody pair (dual-set) for ELISA assay. All of our monoclonal or polyclonal antibody reagents are generated from immunization with recombinant hemagglutinin (HA) protein antigen, and hence should have better specificity and affinity than antibody raised from peptide based antigen. We are committed to develop innovative and cost-effective solutions. More influenza related protein and antibody reagents are coming.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"