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Influenza A H9N2 NA / Neuraminidase PDF Download

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40034-VNAHC
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H9N2 NA / Neuraminidase Protein Datasheet

 

H9N2 NA Protein Price Inquiry ( Available Sizes )

H9N2 NA Protein Product Information

Synonym :

NA

Protein Construction:

A DNA sequence encoding the Influenza A virus (A/Chicken/Hong Kong/G9/97 (H9N2)) neuraminidase was expressed, the cell lysates are collected, and bio-activity was tested

Source: Influenza A Virus H9N2
Expression Host: Human Cells

H9N2 NA Protein QC Testing

Bio-activity:

Measured by its ability to cleave a fluorogenic substrate, 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid

The specific activity is > 500 U

One unit is defined as the amount of enzyme required to cleave 1 nmole of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid per minute at pH 7.5 at 37℃.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Molecular Mass:

The influenza H9N2 virus Neuraminidase comprises 469 amino acids

Formulation: Lyophilized from sterile PBS, 0.6% Triton X-100, 7% Trehalose, 6% Mannitol, pH7.4

Please contact us for any concerns or special requirements.

H9N2 NA Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that 1 ml sterile water be added to the vial to prepare a stock solution.

Related Influenza Virus Research Tools

  • Influenza Neuraminidase Protein & Antibody
  • Influenza Neuraminidase / Influenza NA Proteins
  • H9N2 NA Protein Description

    Neuraminidase ( NA ) is a major membrane glycoproteins found on the surface of influenza virus. NA specifically catalyzes the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle, NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. NA thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. NA is a single-pass type I I membrane protein which exists as a homotetramer, and the transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, and subtypes N1 and N2 have been positively linked to epidemics in man.

    References

    1. Suzuki T. et al., 2005, J Virol. 79: 11705-15.
    2. Shinya K. et al., 2006, Nature. 440 (7083): 435-6.
    3. Von Itzstein M. 2007, Nat Rev Drug Discov. 6: 967-74.
    4. Christophe F. et al., 2009, Science. 324: 1557-61.
    5. Marjuki H. et al., 2006, J Biol Chem. 281: 16707-15.
    6. Christophe F. et al., 2009, Science. 324:1557-61.
 

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Protein : hemagglutinin (HA)neuraminidase (NA)nucleoprotein (NP)matrix protein 1 (M1)nonstructural protein 1 (NS1)nonstructural protein 2 (NS2)influenza antigen (influenza protein)
Antibody : hemagglutinin antibodyneuraminidase antibodynucleoprotein antibodymatrix protein 1 antibodyH1N1 antibodyH5N1 antibodyH3N2 antibodyH9N2 antibodyH2N2 antibodyH4N6 antibodyH11N2 antibodyH12N5 antibodyH15N8 antibodyH16N3 antibodyinfluenza B antibody
ELISA Kit : Influenza ELISA Kit
Gene : Influenza Gene / Influenza cDNA Clone

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HA

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H4N4-HA H4N6-HA H4N8-HA H5N1-HA H5N2-HA
H5N3-HA H5N8-HA H6N1-HA H6N4-HA H7N7-HA
H8N4-HA H9N2-HA H10N3-HA H10N9-HA H11N2-HA
H11N9-HA H12N1-HA H12N5-HA H13N8-HA H15N8-HA
H16N3-HA Influenza B-HA      

NA

H1N1-NA H5N1-NA H3N2-NA H9N2-NA  

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