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> Influenza A H5N1 Neuraminidase & Antibody (H5N1 NA) Influenza A H5N1 Neuraminidase & Antibody (H5N1 NA)
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H5N1 Neuraminidase (NA) Protein Products
Influenza Neuraminidase (NA) Protein: H5N1, A/Anhui/1/2005
| Product (CLICK for detailed Info. and price) | Species | Molecule | Description | Cat. No |
| Influenza Neuraminidase (NA) Protein H5N1, A/Anhui/1/2005 |
Influenza A H5N1 Virus | NA | Native | 11676-VNAHC |
| Influenza Neuraminidase (NA) Protein H5N1, A/Anhui/1/2005 |
Influenza A H5N1 Virus | NA | Native | 11676-VNAHC1 |
Influenza Neuraminidase (NA) Protein: H5N1, A/Hubei/2011
| Product (CLICK for detailed Info. and price) | Species | Molecule | Description | Cat. No |
| Influenza Neuraminidase (NA) Protein H5N1, A/Hubei/2011 |
Influenza A H5N1 Virus | NA | His Tag | 40018-V07H |
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Additional Influenza Research Reagents
Influenza Neuraminidase (NA) Background
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Neuraminidase, also called sialidases, specifically catalyzes the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle; while NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. Neuraminidase is a single-pass type II membrane protein which exists as a homotetramer. Its transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, of which subtypes N1 and N2 have been positively linked to epidemics in man.
Continuing occurrences of human infections with avian influenza A (H5N1) viruses have ignited increasing fears that the next influenza pandemic is imminent. At present, there are only three licensed anti-Influenza drugs namely Zanamivir, Oseltamivir and Amantadine/Rimantadine. Zanamivir and Oseltamivir target neuraminidase (NA) and were designed through structure-based enzyme inhibitor programmes. Neuraminidase promotes influenza virus release from infected cells and facilitates virus spread within the respiratory tract. The neuraminidase inhibitors interfere with the release of progeny influenza virus from infected host cells, thereby halts the spread of infection in the respiratory tract.
Influenza Neuraminidase (NA) Related Studies
- Gubareva LV, et al. (2000) Influenza virus neuraminidase inhibitors. Lancet. 355(9206):827-35.
- Crusat M, et al. (2007) Neuraminidase inhibitors and their role in avian and pandemic influenza. Antivir Ther. 12(4 Pt B):593-602.
- Sylte MJ, et al. (2009) Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 333:227-41.
- Mitrasinovic PM. (2010) Advances in the structure-based design of the influenza A neuraminidase inhibitors. Curr Drug Targets. 11(3):315-26.
