H1N3 Hemagglutinin & H1N3 Hemagglutinin Antibody

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H1N3 Hemagglutinin & H1N3 Hemagglutinin Antibody Products

H1N3 Hemagglutinin Protein  (2)            A/duck/NZL/160/1976   

Products	Source (CLICK for detailed Info. and Price)	Molecule	Description	Cat No
Protein	H1N3 Hemagglutinin (HA) A/duck/NZL/160/1976	HA	His Tag	11685-V08H
Protein	H1N3 Hemagglutinin (HA) A/duck/NZL/160/1976	HA1	His Tag	11685-V08H1

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H1N3 Hemagglutinin Background

Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. Subtypes are further divided into strains. Each genetically distinct virus isolate is usually considered to be a separate strain.

H1N3 is a subtype of Influenza A. Hemagglutinin (HA) is a Single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. It is a homotrimer of disulfide-linked HA1-HA2. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion “fusion peptide”. After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle’s own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence.

H1N3 Hemagglutinin Related Studies

1. Lvov DK, et al. (1983) Isolation of a natural recombinant of influenza A virus (H1N3) from a sick child. Lancet. 2(8361):1246-7.
2. Vladimirtseva EA, et al. (1985) Physicochemical properties of the RNA and proteins of an influenza virus H1N3 isolated from an ill child and antigenically analogous to A/whale/TO/19/76. Vopr Virusol. 30(2):163-6.
3. von Itzstein M. (2007) The war against influenza: discovery and development of sialidase inhibitors. Nat Rev Drug Discov. 6(12):967-74.
4. Christophe F, et al. (2009) Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings. Science. 324(5934):1557-61.