>Influenza A Nucleoprotein (NP) & Antibody
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Influenza A Nucleoprotein Products
Influenza A Nucleoprotein (NP)
|Product (CLICK for detailed Info. and price)||Species||Molecule||Description||Cat No|
|Influenza A Nucleoprotein (NP)
H1N1, A/Puerto Rico/8/34/Mount Sinai
|Influenza A H1N1 Virus||NP||His Tag||11675-V08B|
|Influenza A H2N2 Virus||NP||His Tag||40033-V08B|
Influenza A Nucleoprotein (NP) Antibody
(CLICK for detailed Info. and price)
|Influenza A Nucleoprotein (NP) Antibody||Influenza A Virus||Rabbit PAb||WB, ELISA||11675-RP01|
|Influenza A Nucleoprotein (NP) Antibody||Influenza A Virus||Rabbit PAb||WB, ELISA||11675-RP02|
|Influenza A Nucleoprotein (NP) Antibody||Influenza A Virus||Mouse MAb||WB, ELISA||11675-MM03|
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Influenza A Nucleoprotein (NP) Background
Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. Influenza viruses A, B and C are very similar in overall structure. The viral particles of all influenza viruses are similar in composition. These are made of a viral envelope containing two main types of glycoproteins, wrapped around a central core. The central core contains the viral RNA genome and other viral proteins that package and protect this RNA. The influenza A genome contains 11 genes on eight pieces of RNA, encoding for 11 proteins: Hemagglutinin (HA), Neuraminidase (NA), Nucleoprotein (NP), M1, M2, NS1, NS2 (NEP), PA, PB1, PB1-F2 and PB2.
Influenza A virus nucleoprotein (NP) forms homo-oligomers and multiple copies of NP wrap around genomic RNA, along with a trimeric polymerase making up ribonucleoprotein (RNP) complex. Nucleoprotein (NP) is composed of a head and a body domain and a tail loop / linker region. The head domain is more conserved than the body domain. Nucleoprotein (NP) oligomerization is mediated by the insertion of the non-polymorphic and structurally conserved tail loop of one NP molecule to a groove of another NP. The different form of Nucleoprotein (NP) oligomers is due to the flexibility of the polymorphic linkers that join the tail loop to the rest of the protein. The RNA binding property of NP is known to involve the protruding element and the flexible basic loop between the head and body domains, both having high degree of primary sequence conservation.
Influenza antibody and influenza antibodies are very important research tools for influenza diagnosis, influenza vaccine development, and anti-influenza virus therapy development. Monoclonal or polyclonal antibody can be raised with protein based antigen or peptide based antigen. Antibody raised with protein based antigen could have better specificity and/or binding affinity than antibody raised with peptide based antigen, but cost associated with the recombinant protein antigen is usually higher. Anti influenza virus hemagglutinin (HA) monoclonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohistochemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection.
Sino Biological has developed state-of-the-art monoclonal antibody development technology platforms: mouse monoclonal antibody and rabbit monoclonal antibody. Our rabbit monoclonal antibody platform is one of a kind and offers some unique advantages over mouse monoclonal antibodies, such as high affinity, low cross-reactivity with rabbit polyclonal antibodies.
Influenza A Nucleoprotein (NP) Related Studies
- Scholtissek C, et al. (1993) Analysis of influenza A virus nucleoproteins for the assessment of molecular genetic mechanisms leading to new phylogenetic virus lineages. Arch Virol. 131(3-4):237-50.
- Hagiwara K, et al. (2009) Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays. Biochem Biophys Res Commun. 394(3):721-7.
- Ng AK, et al. (2009) Structure and sequence analysis of influenza A virus nucleoprotein. Sci China C Life Sci. 52(5):439-49.