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> Influenza A H1N1 Neuraminidase & Antibody (H1N1 NA) Influenza A H1N1 Neuraminidase & Antibody (H1N1 NA)
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H1N1 Neuraminidase (NA) Antibody Products
Influenza Neuraminidase (NA) Antibody - raised against influenza A H1N1 viruses.
| Product (CLICK for detailed Info. and price) |
Species | Antibody Type |
Application | Cat No |
| Influenza A H1N1 Neuraminidase (NA) Antibody | Influenza A H1N1 Virus | Mouse MAb | WB, ELISA | 11058-MM07 |
| Influenza A H1N1 Neuraminidase (NA) Antibody | Influenza A H1N1 Virus | Rabbit MAb | WB, ELISA | 11058-R001 |
H1N1 Neuraminidase (NA) Protein Products
Influenza Neuraminidase (NA) Protein: H1N1, A/California/04/2009
| Product (CLICK for detailed Info. and price) | Species | Molecule | Description | Cat. No |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | Fc Tag | 11058-V01H |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | His Tag | 11058-V07H |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | His Tag | 11058-V07B |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | Native | 11058-VNAHC |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | Native | 11058-VNAHC1 |
| Influenza Neuraminidase (NA) Protein H1N1, A/California/04/2009 |
Influenza A H1N1 Virus | NA | His Tag | 11058-V07HC |
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Additional Influenza Research Reagents
Influenza Neuraminidase (NA) Background
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Neuraminidase, also called sialidases, specifically catalyzes the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle; while NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. Neuraminidase is a single-pass type II membrane protein which exists as a homotetramer. Its transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, of which subtypes N1 and N2 have been positively linked to epidemics in man.
The notation HnNn is used to refer to the subtype comprising the hth discovered Hemagglutinin (HA) protein and the nth discovered neuraminidase (NA) protein. Influenza viruses that are known to infect human include the following sub-types. H1N1 virus that caused "Spanish Flu" (A/BrevigMission/1/1918(H1N1)) and seasonal flu (A/Brisbane/59/2007(H1N1), A/New Caledonia/20/1999(H1N1), and A/Solomon Islands/3/2006 (H1N1)) and a reassortment virus (A/California/04/2009(H1N1)) that caused the 2009 swine flu outbreak; H2N2 virus that caused the "Asian Flu"; H3N2 virus that caused the "Hong Kong Flu"; H5N1 "The Bird Flu" virus (A/Anhui/1/2005 (H5N1), A/Vietnam/1203/2004, A/Vietnam/1194/2004 (H5N1), A/bar-headed goose/Qinghai/14/2008 (H5N1), A/turkey/1/2005 (H5N1), A/Indonesia/5/2005 (H5N1)) that was the world's major influenza pandemic threat until the Swine Flu Pandemic of 2009; H7N7 virus that has unusual zoonotic potential; H1N2 is currently endemic in humans and pigs; and H9N2, H7N2, H7N3, H10N7 viruses.
Influenza Neuraminidase (NA) Related Studies
- Barman, S., et al. (2000) Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association. J. Virol. 74(14): 6538-45.
- Colman, P.M., et al. (1983) Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 303(5912): 41-4.
- Suzuki, T., et al. (2005) Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication. J. Virol. 79(18): 11705-15.
