Guanylate-binding protein 1 (GBP1)

Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.

Guanylate-binding protein 1 (GBP1) Related Areas

Immunology>>Adaptive Immunity >>GBP1

Guanylate-binding protein 1 (GBP1) Alternative Names

GBP-1, GTP-binding protein 1, OTTHUMP00000012352, guanine nucleotide-binding protein 1 [Homo sapiens]

5830475C06, Gbp-1, MGC124334, Mag-1, Mpa-1, Mpa1[Mus musculus]

Summaries for Guanylate-binding protein 1 (GBP1)

Entrez Gene summary for GBP1:

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

OMIM - description for GBP1:

Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3 (Cheng et al., 1991).

Wikipedia summary for GBP1:

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. GBP1 belongs to the dynamin superfamily of large GTPases

Human Guanylate-binding protein 1 (GBP1) Protein General Information

 

• Protein names: GTP-binding protein 1, Short name=GBP-1
• Sequence length: 592 AA.
• Sequence similarities: GBP1 belongs to the GBP family.
• Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
• Induction: By IFNG/IFN-gamma during macrophage activation.

General information above from UniProt

Function for Guanylate-binding protein 1 (GBP1) Protein

UniProtKB:

GBP1 binds GTP, GDP and GMP.

Genatlas:

• GTPase converting GTP to GMP
• GBP1 mediates an antiviral effect against stomatites virus and encephalomyocarditis virus
• GBP1 is a key mediator of the inhibitory effects of inflammatory cytokines on endothelial cells proliferation and invasiveness
• GBP1 acts as a major regulator of the anti-angiogenic response of endothelial cells to inflammatory cytokines