Anti-Growth Hormone Receptor Antibody

Cat: 50043-RP02
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Anti-Growth Hormone Receptor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Growth Hormone Receptor Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse Growth Hormone Receptor
Immunogen
Recombinant Mouse Growth Hormone Receptor / GHR / GHBP protein (Catalog#50043-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Growth Hormone Receptor / GHR / GHBP (rM Growth Hormone Receptor / GHR / GHBP; Catalog#50043-M08H; NP_034414.2; Met 1-Gln 273). Growth Hormone Receptor / GHR / GHBP specific IgG was purified by Mouse Growth Hormone Receptor / GHR / GHBP affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Growth Hormone Receptor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IHC-P 1:2000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Growth Hormone Receptor Antibody (Rabbit Polyclonal antibody) Images
Mouse Growth Hormone Receptor / GHR / GHBP Immunohistochemistry(IHC) 3280
Immunochemical staining of mouse GHR in mouse stomach with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.
Mouse Growth Hormone Receptor / GHR / GHBP Immunohistochemistry(IHC) 3282
Immunochemical staining of mouse GHR in mouse kidney with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.
Mouse Growth Hormone Receptor / GHR / GHBP Western blot (WB) 13636

Anti-GHR rabbit polyclonal antibody at 1:500 dilution

Lane A: PC-3 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:71 kDa

Observed band size:55 kDa

Anti-Growth Hormone Receptor Antibody Alternative Names
Anti-GHBP Antibody;Anti-GHR/BP Antibody
Growth Hormone Receptor Background Information

Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

Full Name
growth hormone receptor
References
  • Leung DW. et al., 1987, Nature. 330:537-43.
  • Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
  • Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
  • Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
  • Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.
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