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>Growth Factor & Receptor
Growth Factor & Receptor
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Growth Factor & Receptor Background
The term growth factor encompasses a complex family of polypeptide hormones, steroid hormones, or biological factors that are capable of stimulating cell growth, proliferation and differentiation. Growth factors are important for regulating a variety of cellular processes, including regulating tissue morphogenesis, angiogenesis, cell differentiation, and neurite outgrowth. Growth factors typically act as signaling molecules between cells. Activities of growth factors are mediated via binding to transmembrane receptors that often contain cytoplasmic tyrosine kinase domains. For the last two decades, growth factors have been increasingly used in the treatment of hematologic and oncologic diseases and cardiovascular diseases like: neutropenia, myelodysplastic syndrome (MDS), leukemias, aplastic anaemia, bone marrow transplantation, angiogenesis for cardiovascular diseases.
What are Growth Factors
Growth factors, which generally considered as a subset of cytokines, refer to the diffusible signaling proteins that stimulate cell growth, differentiation, survival, inflammation, and tissue repair. More……
History of Growth Factor Discovery
The first growth factor, nerve growth factor was discovered by Stanley Cohen and Rita Levi-Montalcini in 1952. The assumption of a soluble, diffusible agent exist in embryo or sarcoma was made based an interesting phenomenon discovered in the laboratories of Prof. Viktor Hamburger and Rita Levi-Montalcini more than half a century ago. More……
Classes of Growth Factors & Receptors
Numerous growth factors have been isolated, and they are classified into different families on the basis of their target cells, functions, structures and molecular evolution. Some well-known families are demonstrated as follows: More……
Growth Factor Receptors
Growth factor receptors are transmembrane proteins which bind to specific growth factors and transmit the instructions conveyed by the factors to intracellular space. The growth factor receptors on cell surface are very common, and cells mainly contains receptors for several growth factors. More……
Growth Factor Signaling
When a growth factor and its receptor bind together, the receptor can either transiently exert its kinase activity or form a complex with an intracellular tyrosine or serine/threonine kinase. More……
Growth Factors & Receptors in Clinical use
Growth factors play an important role in various cellular processes. The growth factors themselves and their inhibitors or antibodies can be widely used in disease therapy. Nowadays, researchers have made great progress in the treatment of oncologic diseases, cardiovascular diseases, and diabetic mellitus etc. More……
Growth Factor & Receptor Related Studies
- Pardali E, et al. (2009) Transforming growth factor-beta signaling and tumor angiogenesis. Front Biosci. 14:4848-61.
- Galazios G, et al. (2009) Vascular endothelial growth factor gene polymorphisms and pregnancy. J Matern Fetal Neonatal Med. 22(5):371-8.
- Krejci P, et al. (2009) Molecular pathology of the fibroblast growth factor family. Hum Mutat. 30(9):1245-55.
- Fiore M, et al. (2009) Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci. 20(2):133-45.
- Li G, et al. (2010) The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas. Neurosurg Clin N Am. 21(1):87-93.