Anti-Gremlin 1 Antibody

Cat: 50016-RP01
Contact us:
All Gremlin 1 Reagents
CRO Services

All Gremlin 1 Reagents
Anti-Gremlin 1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Gremlin 1 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse Gremlin 1
Recombinant Mouse Gremlin 1 / GREM1 protein (Catalog#50016-M08B)
Produced in rabbits immunized with purified, recombinant Mouse Gremlin 1 / GREM1 (rM Gremlin 1 / GREM1; Catalog#50016-M08B; O70326; Met1-Asp184). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Gremlin 1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Gremlin 1 Antibody Alternative Names
Anti-Cktsf1b1 Antibody;Anti-Drm Antibody;Anti-Grem Antibody;Anti-ld Antibody
Gremlin 1 Background Information

GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as inhibitor of monocyte chemotaxis. GREM1 is highly expressed in small intestine, fetal brain and colon.

Full Name
gremlin 1, DAN family BMP antagonist
  • Dimitrov BI, et al. (2010) Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. J Med Genet. 47(8):569-74.
  • Heron M, et al. (2011) Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. Tissue Antigens. 77(2):112-7.
  • van Vlodrop IJ, et al. (2010) Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol. 176(2):575-84.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Gremlin 1 Antibody Rabbit Monoclonal ELISA 50016-R117
    Anti-Gremlin 1 Antibody Rabbit Polyclonal WB,IHC-P 50016-RP02
    info info
    添加购物车成功! 添加购物车失败!