Anti-Gremlin 1 Antibody

Cat: 50016-RP01
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Anti-Gremlin 1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Gremlin 1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Gremlin 1
Immunogen
Recombinant Mouse Gremlin 1 / GREM1 protein (Catalog#50016-M08B)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Gremlin 1 / GREM1 (rM Gremlin 1 / GREM1; Catalog#50016-M08B; O70326; Met1-Asp184). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Gremlin 1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Gremlin 1 Antibody Alternative Names
Anti-Cktsf1b1 Antibody;Anti-Drm Antibody;Anti-Grem Antibody;Anti-ld Antibody
Gremlin 1 Background Information

GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as inhibitor of monocyte chemotaxis. GREM1 is highly expressed in small intestine, fetal brain and colon.

Full Name
gremlin 1, DAN family BMP antagonist
References
  • Dimitrov BI, et al. (2010) Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. J Med Genet. 47(8):569-74.
  • Heron M, et al. (2011) Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. Tissue Antigens. 77(2):112-7.
  • van Vlodrop IJ, et al. (2010) Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol. 176(2):575-84.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Gremlin 1 Antibody Rabbit Monoclonal ELISA 50016-R117
    Anti-Gremlin 1 Antibody Rabbit Polyclonal WB,IHC-P 50016-RP02
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