Anti-Granzyme B Antibody

Cat: 10345-R002
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All Granzyme B Reagents
CRO Services
Product recommended

All Granzyme B Reagents
Anti-Granzyme B Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Granzyme B Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Granzyme B
Has cross-reactivity in ELISA with Human Granzyme H
Immunogen
Recombinant Human Granzyme B protein (Catalog#10345-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Granzyme B (rh Granzyme B; Catalog#10345-H08H; NP_004122.1; Met 1-Tyr 247) .
Source
Monoclonal Rabbit IgG Clone #2
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Granzyme B Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Granzyme B Antibody (Rabbit Monoclonal antibody) Images
Human Granzyme B/GZMB Immunohistochemistry(IHC) 4089
Immunochemical staining of human Granzyme B in human tonsil with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human Granzyme B/GZMB Immunohistochemistry(IHC) 4091
Immunochemical staining of human Granzyme B in human spleen with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human Granzyme B/GZMB Immunohistochemistry(IHC) 4094
Immunochemical staining of human Granzyme B in human lymph node with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Granzyme B Antibody Alternative Names
Anti-CCPI Antibody;Anti-CGL-1 Antibody;Anti-CGL1 Antibody;Anti-CSP-B Antibody;Anti-CSPB Antibody;Anti-CTLA1 Antibody;Anti-CTSGL1 Antibody;Anti-HLP Antibody;Anti-SECT Antibody
Granzyme B Background Information

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.

Full Name
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
References
  • Schmid J., et al.,(1987), Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139:250-256.
  • Caputo A., et al., (1988), Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.J. Biol. Chem. 263:6363-6369.
  • Trapani J.A., et al.,(1988), Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Granzyme B Antibody Mouse Monoclonal ELISA,IHC-P 10345-MM01
    Anti-Granzyme B Antibody Rabbit Polyclonal ELISA 10345-RP03
    Anti-Granzyme B Antibody Rabbit Polyclonal WB,ELISA 10345-T48
    Anti-Granzyme B Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10345-RP04
    info info
    添加购物车成功! 添加购物车失败!