Granulocyte

Sino biological offers a comprehensive set of tools for granulocyte related research. These include recombinant proteins, monoclonal or polyclonal antibodies and ORF cDNA clones.

Granulocyte Background

Granulocytes, also called polymorphonuclear leukocytes, are a subgroup of leukocytes filled with granules in their cytoplasm. There are three types of granulocytes, basophils, eosinophils and neutrophils. The cell types are named by the distinct staining features of their granules. Granulocytes that have somewhat non-specific, broad-based activity play a role in innate immunity. Basophil granulocytes play a role in mediating hypersensitivity reactions and inflammation. When stimulated, basophils release histamine and other enzymes that can lead to inflammation, bronchoconstriction, and asthma symptoms. Eosinophil granulocytes are responsible for combating multicellular parasites and certain infections, as well as mediating allergic responses and asthma pathogenesis, along with basophils and mast cells. Stimulated eosinophils release an array of cytotoxic proteins contained in their granules to destroy invasive entities and combat infection. Neutrophil granulocytes can directly attack invading pathogens by phagocytosis, as well as activate other cells in the immune system.

Granulocyte Related Studies

1. Bianchi SM, et al. (2006) Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clin Sci (Lond). 110(3):293-304.
2. Littlewood TJ, et al. (2007) Granulocyte and erythropoietic stimulating proteins after high-dose chemotherapy for myeloma. Bone Marrow Transplant. 40(12):1147-55.
3. Leitch AE, et al. (2008) Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa. Mucosal Immunol. 1(5):350-63.
4. Peters C. (2009) Granulocyte transfusions in neutropenic patients: beneficial effects proven? Vox Sang. 96(4):275-83.