Granulin / Progranulin Protein & Antibody (Proepithelin)

Granulin / Progranulin Products

Granulin / Progranulin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Granulin/Progranulin	Human	Granulin/Progranulin Protein, Recombinant	10826-H08H
Granulin/Progranulin	Mouse	Granulin/Progranulin Protein, Recombinant	50396-M08H

Granulin / Progranulin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Granulin/Progranulin	WB	Mouse Monoclonal Antibody	10826-MM01
Human Granulin/Progranulin	ELISA	Mouse Monoclonal Antibody	10826-MM02
Human Granulin/Progranulin	WB, ELISA	Rabbit Polyclonal Antibody	10826-RP03
Human Granulin/Progranulin	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10826-RP04
Human Granulin/Progranulin	WB, ELISA	Granulin/Progranulin Antibody, Rabbit MAb	10826-R007
Mouse Granulin/Progranulin	WB, ELISA	Granulin/Progranulin Antibody, Rabbit PAb	50396-RP01
Mouse Granulin/Progranulin	WB, ELISA	Granulin/Progranulin Antibody, Rabbit PAb (Antigen Affinity Purified)	50396-RP02
Mouse Granulin/Progranulin	ELISA	Granulin / Progranulin / GRN Antibody	50396-R017
Mouse Granulin/Progranulin	ELISA	Granulin / Progranulin / GRN Antibody	50396-R034

Granulin / Progranulin ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Granulin/Progranulin	ELISA	Granulin/Progranulin ELISA Kit	SEK10826

Granulin / Progranulin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Granulin/Progranulin	Human	Homo sapiens Granulin/Progranulin cDNA Clone(NM_002087.2)	HG10826-M
Granulin/Progranulin	Mouse	Mus musculus Granulin/Progranulin cDNA Clone	MG50396-M

Granulin / Progranulin Related Areas

Cancer>>Growth Factor>>Granulin/Epithelin Family>>Granulin/Progranulin/GRN

Granulin / Progranulin Alternative Names

Granulin, progranulin, proepithelin, PCDGF, GRN, GEP, GP88, PEPI, PGRN, granulin-epithelin, granulins [Homo sapiens]

Granulin, progranulin, proepithelin, PCDGF, Grn, RP23-226P4.4, epithelin, PEPI, acrogranulin, granulins [Mus musculus]

Granulin / Progranulin Background

&Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

Granulin / Progranulin Related Studies

1. Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
2. Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
3. Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.