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Granulin / Progranulin / GRN Antibody Datasheet
|Order or Inquire for Granulin / Progranulin / GRN Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
Granulin / Progranulin / GRN Antibody Product Information
Recombinant Mouse Granulin / Progranulin / GRN protein (Catalog#50396-M08H)
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Granulin / Progranulin / GRN (rM Granulin / Progranulin / GRN; Catalog#50396-M08H; NP_032201.2; Met 1-Leu 589).
Granulin / Progranulin / GRN Antibody Usage Guide
Mouse Granulin / Progranulin / GRN
No cross-reactivity in ELISA with
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse GRN. The detection limit for Mouse GRN is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Granulin / Progranulin / GRN Antibody Related Products & Topics
Granulin / Progranulin / GRN Antibody Background
Granulin (GRN), also known as PC cell derived growth factor (PCDGF), is a ubiquitously expressed 88 kDa secreted, glycosylated protein which contains seven tandem repeats (55-57 aa consensus) of a highly conserved 12-cysteine granulin/epithelin motif. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Both the peptides and intact granulin protein regulate cell growth. Different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth, and thus perform important functions in normal development, wound healing, and tumorigenesis.Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD), an autosomal dominant neurodegenerative.
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