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Progranulin/Granulin Rabbit PAb

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    Mouse GRN Antibody Product Information
    Immunogen:Recombinant Mouse GRN protein (Catalog#50396-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse Granulin (rM Granulin; Catalog#50396-M08H; NP_032201.2; Met 1-Leu 589). Total IgG was purified by Protein A affinity chromatography .
    Other GRN Antibody Products
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    • Slide 1
    10826-RP04-50
    10826-RP04-200
    10826-RP04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IF  ICC/IF  
    • Slide 1
    10826-MM02-50
    10826-MM02-200
    10826-MM02-100
    10826-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    Reactivity: Human  
    Application: 
      10826-MM10-50
      10826-MM10-200
      10826-MM10-100
      10826-MM10-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10826-R007-50
        10826-R007-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
        • Slide 1
        10826-RP03-400
        10826-RP03-200
        10826-RP03-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: 
          50396-R019-50
          50396-R019-100
          50396-R019-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50396-R017-50
            50396-R017-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  IHC-P  
            • Slide 1
            • Slide 1
            50396-RP02-50
            50396-RP02-200
            50396-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50396-R034-50
              50396-R034-100
              50396-R034-1
              50 µg 
              100 µg 
              1 mg 
              Add to Cart

              Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

              Lane A: NIH3T3 Whole Cell Lysate

              Lane B: Hela Whole Cell Lysate

              Lysates/proteins at 30 μg per lane.

              Secondary

              Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

              Developed using the ECL technique.

              Performed under reducing conditions.

              Predicted band size:15 kDa

              Observed band size:17 kDa

              Progranulin/Granulin Background

              &Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

              Mouse Progranulin/Granulin References
            • Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
            • Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
            • Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.
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              Size / Price
              Catalog: 50396-RP01-400
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              Datasheet & Documentation

              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"