Anti-Granulin Antibody

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Anti-Granulin Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Granulin Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Granulin
Immunogen
Recombinant Human GRN protein (Catalog#10826-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human GRN / Granulin (rh GRN; Catalog#10826-H08H; Met 1-Leu 593; NP_002078.1). GRN specific IgG was purified by human GRN affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Granulin Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Granulin Antibody (Rabbit Polyclonal antibody) Images

Immunohistochemical staining of formalin fixed, paraffin-embedded human placenta showing trophoblastic cell staining (red arrow). The left panel: 1:1000. The right panel: 1:1000.
Immunohistochemical staining of formalin fixed, paraffin-embedded human epididymis showing epithelium cells staining (red arrow). The left panel: 1:1000. The right panel: 1:1000.

Anti-Granulin Antibody: Alternative Names

Anti-CLN11 Antibody; Anti-GEP Antibody; Anti-GP88 Antibody; Anti-Granulin Antibody; Anti-PCDGF Antibody; Anti-PEPI Antibody; Anti-PGRN Antibody; Anti-Progranulin Antibody

Granulin Background Information

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.
Full Name
Granulin Precursor
References
  • Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
  • Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
  • Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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