Grancalcin / GCA Protein

Grancalcin Products

Grancalcin Protein, Recombinant

Molecule	Species	Description	Cat. No
Grancalcin	Human	GCA/Grancalcin Protein, Recombinant	12556-H07E

Grancalcin Related Areas

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>Grancalcin

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>Grancalcin

Grancalcin Alternative Names

Grancalcin, GCA, GCL [Homo sapiens]

Grancalcin, Gca, RP23-34J8.3, 5133401E04Rik, AI573844 [Mus musculus]

Grancalcin Background

Grancalcin, or GCA, is a Ca(2+)-binding protein expressed at high level in neutrophils. It belongs to the PEF family, proteins containing five EF-hand motifs and which are known to associate with membranes in Ca(2+)-dependent manner. Grancalcin interacts with L-plastin, a protein known to have actin bundling activity, suggests that grancalcin may play a role in regulation of adherence and migration of neutrophils. The Grancalcin protein especially abundant in human neutrophils. The association of a high proportion of this protein with the membranes and granules in the presence of physiological concentrations of calcium may indicate a role in granule-membrane fusion and degranulation. And Grancalcin also plays a key role in leukocyte-specific functions that are responsible for host defense.

Grancalcin Related Studies

1. Liu F, et al. (2004) Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection. Biosci Biotechnol Biochem. 68(4): 894-902.
2. Lollike K, et al. (2001) Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem. 276(21): 17762-9.
3. Jia J, et al. (2000) Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 300(5): 1271-81.
4. Teahan CG, et al. (1992) Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J. 286 (Pt 2): 549-54.