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GCA/Grancalcin Protein, Antibody, ELISA Kit, cDNA Clone

GCA/Grancalcin Related Areas

GCA/Grancalcin Related Pathways

GCA/Grancalcin Related Product

GCA/Grancalcin Summary & Protein Information

GCA/Grancalcin Background

Gene Summary: This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. Grancalcin belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Homodimer. Interacts with SRI and LCP1.
Subcellular location: Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.
Tissue specificity: Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.
Induction: Up-regulated in the majority of hepatitis C virus- associated hepatocellular carcinoma.
Post-translational: N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).
Sequence similarity: Contains 4 EF-hand domains.
General information above from UniProt

GCA/Grancalcin Alternative Name

GCA/Grancalcin Related Studies

  • Liu F, et al. (2004) Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection. Biosci Biotechnol Biochem. 68(4): 894-902.
  • Lollike K, et al. (2001) Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem. 276(21): 17762-9.
  • Jia J, et al. (2000) Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 300(5): 1271-81.
  • Teahan CG, et al. (1992) Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J. 286 (Pt 2): 549-54.
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