- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
>Grancalcin / GCA Protein
Grancalcin / GCA Protein
Grancalcin Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Grancalcin||Human||GCA/Grancalcin Protein, Recombinant||12556-H07E|
Grancalcin Related Areas
Grancalcin Alternative Names
Grancalcin, GCA, GCL [Homo sapiens]
Grancalcin, Gca, RP23-34J8.3, 5133401E04Rik, AI573844 [Mus musculus]
Grancalcin, or GCA, is a Ca(2+)-binding protein expressed at high level in neutrophils. It belongs to the PEF family, proteins containing five EF-hand motifs and which are known to associate with membranes in Ca(2+)-dependent manner. Grancalcin interacts with L-plastin, a protein known to have actin bundling activity, suggests that grancalcin may play a role in regulation of adherence and migration of neutrophils. The Grancalcin protein especially abundant in human neutrophils. The association of a high proportion of this protein with the membranes and granules in the presence of physiological concentrations of calcium may indicate a role in granule-membrane fusion and degranulation. And Grancalcin also plays a key role in leukocyte-specific functions that are responsible for host defense.
Grancalcin Related Studies
- Liu F, et al. (2004) Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection. Biosci Biotechnol Biochem. 68(4): 894-902.
- Lollike K, et al. (2001) Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem. 276(21): 17762-9.
- Jia J, et al. (2000) Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 300(5): 1271-81.
- Teahan CG, et al. (1992) Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J. 286 (Pt 2): 549-54.