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GCA/Grancalcin Protein, Antibody, ELISA Kit, cDNA Clone

GCA/Grancalcin Related Areas

GCA/Grancalcin Related Pathways

GCA/Grancalcin Related Product

    GCA/Grancalcin Summary & Protein Information

    GCA/Grancalcin Background

    Gene Summary: This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. Grancalcin belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Homodimer. The monomeric form is inactive while the homodimer is active.
    Subcellular location: Endoplasmic reticulum. Golgi apparatus. Lysosome (By similarity). Secreted. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin (By similarity).
    Tissue specificity: Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level).
    Induction: Up-regulated in the majority of hepatitis C virus- associated hepatocellular carcinoma.
    Post-translational: N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).
    Sequence similarity: Belongs to the peptidase M28 family.
    General information above from UniProt

    GCA/Grancalcin Alternative Name

    GCA/Grancalcin Related Studies

  • Liu F, et al. (2004) Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection. Biosci Biotechnol Biochem. 68(4): 894-902.
  • Lollike K, et al. (2001) Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem. 276(21): 17762-9.
  • Jia J, et al. (2000) Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 300(5): 1271-81.
  • Teahan CG, et al. (1992) Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J. 286 (Pt 2): 549-54.
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