Glypican 5 / GPC5 Protein

Glypican 5 / GPC5 Products

Glypican 5 / GPC5 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Glypican 5/GPC5	Human	Glypican-5/GPC5 Protein, Recombinant	10079-H08B

  10079-H08B: Immobilized human GPC5 at 5 µg/ml (100 µl/well) can bind human bFGF with a linear ranger of 0.156-2.5 ng/ml. Measured by its binding ability in a functional ELISA.

Glypican 5 / GPC5 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Glypican 5/GPC5	Human	Homo sapiens Glypican-5/GPC5 cDNA Clone	HG10079-M

Glypican 5 / GPC5 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Glypican 5/GPC5

Glypican 5 / GPC5 Alternative Names

Glypican 5, GPC5, glypican-5, bA93M14.1, glypican proteoglycan 5 [Homo sapiens]

Glypican 5, GPC5, glypican-5, A230034F01Rik [Mus musculus]

Glypican 5 / GPC5 Background

Glypican-5 (GPC5), is a cell membrane protein which belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control of cell division and growth regulation. So far, six members (Glypican-1/GPC1, Glypican-2/GPC2, Glypican-3/GPC3, Glypican-4/GPC4, Glypican-5/GPC5, Glypican-6/GPC6) of this family are known in vertebrates. In adult, Glypican-5 is primarily expressed in the brain. It is also detected in fetal brain, lung and liver. Glypican-5 enhances the intracellular signaling of FGF2 and HGF. It alters the cellular distribution of FGF2. The properties of Glypican-5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and/or overexpress its gene. Glypican-5 is over-expressed in lymphoma cell lines that had shown amplification. It is a likely target for amplification, and that over-expression of GPC5 may contribute to development and/or progression of lymphomas and other tumors.

Glypican 5 / GPC5 Related Studies

1. Yu W, et al. (2003) GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J Hum Genet. 48(6): 331-5.
2. Williamson D, et al. (2007) Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Cancer Res. 67(1): 57-65.