Glypican 3 / GPC3 Protein (OCI-5 Protein)

Glypican 3 / GPC3 Protein Products

Glypican 3 / GPC3 Protein, Recombinant

Molecule	Species	Description	Cat. No
Glypican 3/GPC3/OCI-5	Human	Glypican-3/GPC3 Protein, Recombinant	10088-H08H

  10088-H08H: Immobilized human GPC3 at 5 µg/ml (100 µl/well) can bind human bFGF/FGF2 with a linear ranger of 0.156-2.5 ng/ml. Measured by its binding ability in a functional ELISA.

Glypican 3 / GPC3 cDNA Clone

Molecule	Species	Description	Cat. No
Glypican 3/GPC3/OCI-5	Human	Homo sapiens Glypican 3/GPC3/OCI-5 cDNA Clone(NM_004484.2)	HG10088-M
Glypican 3/GPC3/OCI-5	Mouse	Mouse Glypican 3/GPC3/OCI-5 cDNA Clone / ORF Clone	MG50989-G

Glypican 3 / GPC3 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Glypican 3/GPC3/OCI-5

Cancer>>Cancer Biomarkers>>Glypican 3/GPC3/OCI-5

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Glypican 3/GPC3/OCI-5

Glypican 3 / GPC3 Alternative Names

Glypican 3, GPC3, OCI-5, AC002420.1, DGSX, GTR2-2, MXR7, SDYS, SGB, SGBS, SGBS1 [Homo sapiens]

Glypican 3, GPC3, OCI-5, RP23-33P21.1 [Mus musculus]

Glypican 3 / GPC3 Background

Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

Glypican 3 / GPC3 Related Studies

1. Kandil DH, et al. (2009) Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 16(2): 125-9.
2. Maeda D, et al. (2009) Glypican-3 expression in clear cell adenocarcinoma of the ovary. Mod Pathol. 22(6): 824-32.