Glucosamine (N-acetyl)-6-Sulfatase Protein & Antibody (GNS)

Glucosamine (N-acetyl)-6-Sulfatase Products

Glucosamine (N-acetyl)-6-Sulfatase Protein, Recombinant

Molecule	Species	Description	Cat. No
GNS/G6S	Human	GNS/G6S Protein, Recombinant	10319-H08H

Glucosamine (N-acetyl)-6-Sulfatase Antibody

Molecule	Application	Description	Cat. No
Human GNS/G6S	WB, ELISA	Mouse Monoclonal Antibody	10319-MM01
Human GNS/G6S	WB, ELISA	GNS/G6S Antibody, Rabbit MAb	10319-R007
Human GNS/G6S	WB, ELISA	Rabbit Polyclonal Antibody	10319-RP02
Human GNS/G6S	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10319-RP03

Glucosamine (N-acetyl)-6-Sulfatase cDNA Clone

Molecule	Species	Description	Cat. No
GNS/G6S	Human	Homo sapiens GNS/G6S cDNA Clone(NM_002076.3)	HG10319-M

Glucosamine (N-acetyl)-6-Sulfatase Related Areas

Enzyme>>Sulfatase & Sulfotransferase>>Glucosamine (N-acetyl)-6-Sulfatase/GNS

Enzyme>>Carbohydrate Metabolism Enzymes>>Glucosamine (N-acetyl)-6-Sulfatase/GNS

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Glucosamine (N-acetyl)-6-Sulfatase/GNS

Glucosamine (N-acetyl)-6-Sulfatase Alternative Names

Glucosamine (N-acetyl)-6-Sulfatase, GNS, G6S, MGC21274 [Homo sapiens]

Glucosamine (N-acetyl)-6-Sulfatase, Gns, G6S, 2610016K11Rik, AU042285, C87209, N28088 [Mus musculus]

Glucosamine (N-acetyl)-6-Sulfatase Background

Glucosamine (N-acetyl)-6-sulfatase (GNS), also known as G6S, a hydrolase, which is one of the enzymes involved in heparan sulfate catabolism leading to lysosomal storage. GNS is required for the catabolism of the glycosaminoglycans (GAG) including heparin, heparan sulphate, and keratan sulphate through the hydrolysis of 6-sulfate group from the N-acetyl-D-glucosamine 6-sulfate units. Mucopolysaccharidosis type IIID (MPS IIID) is the least common of the four subtypes of Sanfilippo syndrome. It is caused by a deficiency of N-acetylglucosamine-6-sulphatase. A mutation in GNS resulting in MPS IIID indicates the potential utility of molecular diagnosis for this rare condition. As the least common type of the four subtypes of Sanfilippo syndrome, MPS IIID has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.

Glucosamine (N-acetyl)-6-Sulfatase Related Studies

1. Fuchs W, et al. (1985) Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate. Eur J Biochem. 151(3): 551-6.
2. Beesley CE, et al. (2003) Sanfilippo syndrome type D: identification of the first mutation in the N-acetylglucosamine-6-sulphatase gene. J Med Genet. 40(3): 192-4.
3. Mok A, et al. (2003) Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. Genomics. 81(1): 1-5.
4. Elçioglu NH, et al. (2009) A novel loss-of-function mutation in the GNS gene causes Sanfilippo syndrome type D. Genet Couns. 20(2): 133-9.