Glaucoma Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
Carbonic Anhydrase II	CA2, CA-II, CAII, Car2				HG10478-M
Carbonic Anhydrase III	CA3, CAIII, Car3				HG10503-M
Carbonic Anhydrase IV	CA4, CAIV, Car4, RP17				HG10472-M
Carbonic Anhydrase IX	CAIX, CA9, MN	Carbonic anhydrases IX (CAIX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CA9 is thus regarded as a new therapeutic target for CA9-derived carcinomas.	10107-H02H, 10107-H08H	10107-RP01, 10107-RP02	HG10107-M
Carbonic Anhydrase VIII	CA8, CA-VIII, CALS, CAMRQ3, CARP, MGC120502, MGC99509				HG10063-M
Carbonic Anhydrase X	CA10, CA-RPX, CARPX, HUCEP-15	Carbonic anhydrase X, also called carbonic anhydrase - related protein X (CARPX) and CA10, belongs to the CA family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide in various biological processes such as respiration, renal tubular acidification and bone resorption. The secreted protein CARPX without CA activity (hydration of CO2) is identified as an acatalytic member of the alpha-carbonic anhydrase subgroup.	10687-H03H, 10687-HCCH		HG10687-M
Carbonic Anhydrase XII	CAXII, CA12, FLJ20151, HsT18816	Carbonic Anhydrase XII (CA12), also known as Car12 and carbonic anhydrase XII, is a type I membrane enzyme. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker.	10617-H08H, 50014-M08H		HG10617-M, MG50014-M
Carbonic Anhydrase XIII	CA13, CAXIII, FLJ37995, MGC59868				HG10461-M
Carbonic Anhydrase XIV	CAXiV, CA14	The Carbonic Anhydrase XIV (CA XIV/CA14) protein is expressed in the brain on plasma membranes of neuronal bodies and axons, in the kidney preferentially on the apical membranes of proximal tubules, and in the liver on the plasma membranes of hepatocytes. CA14, together with CA4, play important roles in the regulation of intracellular pH in hippocampal neurons by facilitating AE3-mediated Cl––HCO3- exchange.	10458-H08H, 50013-M08H		HG10458-M, MG50013-M
Carbonic Anhydrase VA	CA5A, CA5, CAV, CAVA				HG10500-M