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Gastric intrinsic factor / GIF

Gastric intrinsic factor / GIF Protein & Antibody

Entrez Gene Summary for Gastric intrinsic factor / GIF


GIF gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in GIF gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

OMIM-Description for Gastric intrinsic factor / GIF


.zh=Gastric intrinsic factor / GIF


Intrinsic factor (IF) also known as gastric intrinsic factor (GIF) is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene.
Upon entry into the stomach, vitamin B12 becomes bound to haptocorrin (R factor), a glycoprotein. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.

Gastric intrinsic factor / GIF Alternative Names

gastric intrinsic factor,IF,IFMH,INF,intrinsic factor,TCN3, [human]
AV073125,IF,INF,intrinsic factor, [mouse]

Gastric intrinsic factor / GIF Related Products

Gastric intrinsic factor / GIF Proteins

Product nameProduct name
Human Gastric intrinsic factor / GIF Protein (His Tag)

Gastric intrinsic factor / GIF Antibodies

Product nameProduct name
Gastric intrinsic factor / GIF Antibody, Rabbit PAb, Antigen Affinity PurifiedGastric intrinsic factor / GIF Antibody, Rabbit PAb

Gastric intrinsic factor / GIF cDNA Clones

Product nameProduct name
Human GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHuman GIF Gene cDNA Clone (full-length ORF Clone)Human GIF Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHuman GIF Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tag

Gastric intrinsic factor / GIF ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"