Gene Summary: Galectins, such as LGALS8, are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains (CRDs). Galectins are involved in various biologic processes, including cell signaling, proliferative control, cell adhesion, and cell migrationGeneral information above from NCBI
Cofactor: Divalent metal ions (By similarity).
Subunit structure: Homodimer.
Domain: Contains two homologous but distinct carbohydrate-binding domains.
Subcellular location: Cytoplasm (Probable).
Tissue specificity: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Sequence similarity: Contains 2 galectin domains.
General information above from UniProt
Levy Y, et al. (2003) Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. J Biol Chem. 278(16):14533-42.
Nishi N, et al. (2003) Galectin-8 modulates neutrophil function via interaction with integrin alphaM. Glycobiology. 13(11):755-63.
Bidon-Wagner N, et al. (2004) Human galectin-8 isoforms and cancer. Glycoconj J. 19(7-9):557-63.