Galectin-1 Protein (GAL, LGALS1 Protein)

Lectin, Galactose binding, soluble 1

Galectin-1 Products

Galectin-1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Galectin-1/GAL1/LGALS1	Human	Galectin-1 Protein, Recombinant	10290-HNAE
Galectin-1/GAL1/LGALS1	Mouse	Galectin-1 Protein, Recombinant, Native	50100-MNAE

Galectin-1 Antibody

Molecule	Species	Description	Cat. No
Galectin-1/GAL1/LGALS1	Human	Galectin-1 Antibody (Antigen Affinity Purified)	10290-RP02

Galectin-1 cDNA Clone

Molecule	Species	Description	Cat. No
Galectin-1/GAL1/LGALS1	Human	Homo sapiens Galectin-1 cDNA Clone(NM_002305.3)	HG10290-M
Galectin-1/GAL1/LGALS1	Mouse	Mus musculus Galectin-1 cDNA Clone	MG50100-M

Galectin-1 Alternative Names

Galectin-1, LGALS1, GAL1, GBP, DKFZp686E23103 [Homo sapiens]

Galectin-1, Lgals1, Gal-1, Galbp, L-14.5, L14, Lect14, AA410090 [Mus musculus]

Galectin-1 Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>Galectin-1

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>Galectin-1

Immunology>>Adhesion Molecule>>Lectin>> Galectin-1

Galectin-1 Background

Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.

Galectin-1 Related Studies

1. Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25.
2. Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets. 6(4): 375-83.
3. Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R.
4. Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.