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Galectin-1 / LGALS1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human Galectin-1/LGALS1 Antibody Product Information
Immunogen:Recombinant Human Galectin-1 protein (Catalog#10290-HNAE)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human Galectin-1 (rh Galectin-1 ; Catalog#10290-HNAE; NP_002296.1; Met 1-Asp 135). Galectin-1 specific IgG was purified by Human Galectin-1 affinity chromatography.
Human Galectin-1/LGALS1 Antibody Usage Guide
Specificity:Human Galectin-1
Application:WB, ELISA

WB: 0.5-10 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Galectin 1. The detection limit for Human Galectin 1 is approximately 0.00975 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human Galectin-1/LGALS1 Antibody WB Application Image
Other Galectin-1/LGALS1 Antibody Products
Reactivity: Human  
Application: IHC-P  
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10290-MM01-100
10290-MM01-50
10290-MM01-200
100 µg 
50 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: WB  IP  
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10290-MM02-50
10290-MM02-100
10290-MM02-200
50 µg 
100 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10290-MM04-50
    10290-MM04-100
    10290-MM04-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10290-R008-50
      10290-R008-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: WB  IP  
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      10290-R001-50
      10290-R001-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10290-RP01-100
        10290-RP01-200
        10290-RP01-400
        100 µg 
        200 µg 
         
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  
          80248-RP01-400
          80248-RP01-100
          80248-RP01-200
           
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  WB  IP  
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          80248-T52-200
          80248-T52-100
          80248-T52-50
          200 µg 
          100 µg 
          50 µg 
          Add to Cart
          Galectin-1/LGALS1 Background

          Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.

          Human Galectin-1/LGALS1 References
        • Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25.
        • Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets. 6(4): 375-83.
        • Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R.
        • Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"