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Galactolipase / PNLIPRP2

Galactolipase / PNLIPRP2 Protein & Antibody

Entrez Gene Summary for Galactolipase / PNLIPRP2


OMIM-Description for Galactolipase / PNLIPRP2


Pancreatic lipase (PNLIP; 246600) fulfills a key function in dietary fat absorption by hydrolyzing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. By screening a human pancreas cDNA library with degenerate oligonucleotides designed from the amino acid sequences of human, canine, and porcine PNLIP, Giller et al. (1992) isolated cDNAs encoding 2 novel PNLIP-related proteins, PNLIPRP1 (604422) and PNLIPRP2, which they called PLRP1 and PLRP2, respectively. The predicted 469-amino acid PNLIPRP2 protein contains a 17-amino acid signal peptide and the conserved residues of the lipase catalytic triad and oxy-anion hole. Among known lipases, PNLIPRP2 was most related to a mouse T-cell lipase (Grusby et al., 1990), with 74% amino acid identity. PNLIPRP2 has 65% amino acid sequence identity with PNLIP, 63% identity with PNLIPRP1, and 20 to 30% identity with human gastric lipase (601980), lipoprotein lipase (238600), and hepatic lipase (151670). Western blot analysis of recombinant PNLIPRP2 expressed in mammalian cells detected a secreted, approximately 50-kD protein; the authors concluded that PNLIPRP2 was glycosylated. In a standard pancreatic lipase assay, recombinant PNLIPRP2 showed lipolytic activity that was marginally increased by the addition of colipase and was inhibited by the lipase inhibitor orlistat. Northern blot analysis of pancreas RNA detected major 2.3- and 1.8-kb PNLIPRP2 transcripts. The expression level of PNLIPRP2 in pancreas was approximately 24-fold lower and 6-fold lower than the expression levels of PNLIP and PNLIPRP1, respectively.

.zh=Galactolipase / PNLIPRP2


In enzymology, a galactolipase (EC 3.1.1.26) is an enzyme that catalyzes the chemical reaction
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O=3-beta-D-galactosyl-sn-glycerol + 2 carboxylates
Thus, the two substrates of this enzyme are 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol and H2O, whereas its two products are 3-beta-D-galactosyl-sn-glycerol and carboxylate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase. Other names in common use include galactolipid lipase, polygalactolipase, and galactolipid acylhydrolase. This enzyme participates in glycerolipid metabolism.

Galactolipase / PNLIPRP2 Alternative Names

PLRP2, [homo-sapiens]
galactolipase,PLRP2,PL-RP2, [human]
cytotoxic T-lymphocyte lipase,galactolipase,PLRP2,PL-RP2, [mouse]
PLRP2, [mus-musculus]

Galactolipase / PNLIPRP2 Related Products

Galactolipase / PNLIPRP2 Proteins

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Human Galactolipase / PNLIPRP2 Protein (His Tag)

Galactolipase / PNLIPRP2 Antibodies

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Galactolipase / PNLIPRP2 cDNA Clones

Product nameProduct name
Cynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmidCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-His tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Myc tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-His tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Myc tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Flag tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-His tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Myc tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-HA tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-HA tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-His tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Myc tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-HA tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-HA tagMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone in cloning vectorMouse Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmidCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-His tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-HA tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-HA tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-His tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Flag tagHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmidHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone in cloning vectorHuman Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-Flag tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone in cloning vectorCynomolgus Galactolipase / PNLIPRP2 Gene ORF cDNA clone expression plasmid, N-Myc tag

Galactolipase / PNLIPRP2 ELISA

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