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Galactolipase (PNLIPRP2)

Galactolipase, also known as PNLIPRP2, is a lipase with broad substrate specificity. It can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactolipids. It also hydrolyses milk fat with a lower catalytic efficiency. The expressed galactolipase shows a lipolytic activity that is, however, only marginally dependent on the presence of colipase. The lipolytic activity of pancreatic extracts and human pancreatic juice on Labrasol is mainly due to the combined action of carboxyl ester hydrolase and galactolipase.

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Galactolipase Proteins

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Galactolipase (PNLIPRP2) Alternative Names

PLRP2, PL-RP2, galactolipase [Homo sapiens]

PLRP2, PL-RP2, cytotoxic T-lymphocyte lipase, galactolipase [Mus musculus]

Summaries for Galactolipase (PNLIPRP2)

Wikipedia summary for Galactolipase:

In enzymology, a galactolipase (EC is an enzyme that catalyzes the chemical reaction
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O=3-beta-D-galactosyl-sn-glycerol + 2 carboxylates
Thus, the two substrates of this enzyme are 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol and H2O, whereas its two products are 3-beta-D-galactosyl-sn-glycerol and carboxylate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase. Other names in common use include galactolipid lipase, polygalactolipase, and galactolipid acylhydrolase. This enzyme participates in glycerolipid metabolism.

Human Galactolipase (PNLIPRP2) Protein General Information


Protein names


Sequence length

469 AA.

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.

Sequence similarities:

Galactolipase belongs to the AB hydrolase superfamily. Lipase family. Galactolipase contains 1 PLAT domain.

Subcellular location: Secreted
Tissue specificity


General information above from UniProt

Function for Galactolipase (PNLIPRP2) Protein


Lipase with broad substrate specificity. Galactolipase can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactolipids. Galactolipase contributes to milk fat hydrolysis.


  • Galactolipase has a pancreatic triacylglycerol lipase activity
  • Galactolipase is involved in the digestion of galactolipids, the most abundant lipids occurring in plant cells
  • Galactolipase can hydrolyze triolein emulsified in bile salt micelles in contrast to previous reports
  • Galactolipase acts preferentially on substrates forming monomers or small aggregates (micelles) dispersed in solution like monoglycerides, phospholipids and galactolipids
  • Galactolipase is found to express galactolipase activity, and it is assumed to be the main enzyme involved in the digestion of these common vegetable lipids in the gastrointestinal tract
  • Galactolipase can contribute to fat digestion during early infancy
  • Galactolipase may not function as a triglyceride lipase
  • unlike PNLIP, the activity of Galactolipase is not restored by the addition of another pancreatic protein, colipase
  • Galactolipase's activity was comparable with the activity of CEL, another lipase that contributes to dietary fat digestion in newborns

Homology for human Galactolipase (PNLIPRP2)

  • ortholog to murine Plrp2

Phenotype Information for Galactolipase (PNLIPRP2)

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