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GYS1  Protein, Antibody, ELISA Kit, cDNA Clone

GYS1 Related Pathways

    GYS1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    GYS1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    GYS1 Summary & Protein Information

    GYS1 Background

    Catalytic activity: UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).
    Enzyme regulation: Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).
    Subunit structure: Interacts with GYG1.
    Post-translational: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
    Involvement in disease: Muscle glycogen storage disease 0 (GSD0b) [MIM:611556]: Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the glycosyltransferase 3 family.C
    General information above from UniProt

    GYS1 Alternative Name

    GSY,GYS, [homo-sapiens]
    MGS,Gys3, [mus-musculus]

    GYS1 Related Studies

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