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GSK3B Protein

Glycogen Synthase Kinase 3 Beta

GSK3B Products

GSK3B Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
GSK3B Human GSK3B , Recombinant Protein 10044-H07B
GSK3B Mouse GSK3B Protein, Recombinant 50650-M07B

GSK3B cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
GSK3B Human Homo sapiens GSK3B cDNA Clone(NM_002093.2) HG10044-M
GSK3B Mouse Mus musculus GSK3B cDNA Clone MG50650-M

GSK3B Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>GSK3B

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>GSK3B

GSK3B Alternative Names

GSK3B, GSK3beta isoform [Homo sapiens]

Gsk3b, GSK-3, GSK-3beta, GSK3, 7330414F15Rik, 8430431H08Rik, C86142 [Mus musculus]

 

GSK3B Background

GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in GSK3B gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. GSK3B participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. GSK3B also plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. GSK3B phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. It may be required for early embryo development and neuron differentiation.

GSK3B Related Studies

  1. Bergmann C, et al. (2011) Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis. 70(12):2191-8.
  2. Ban JO, et al. (2011) Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression. Cancer Biol Ther. 12(4):288-96.
  3. Tsukigi M, et al. (2012) Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3β. Cancer Lett. 315(2):189-97.
  4. Nandan D, et al. (2012) Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase. J Immunol. 188(1):367-78.

 

GSK3B related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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