GSK3B Protein

GSK3B Protein Products

Sino Biological is the new leader in life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. All reagents are available in both small retails and bulk packages - both offering 30-80% cost saving compared to currently leading brands. We installed the same quality requirement and assurance for preclinical products to reagent products, hence the quality of Sino Biological products is typically higher than that of other reagent providers.

Sino Biological Inc offers quality GSK3B Protein Products for research .

Browse GSK3B Protein Products by following categories

GSK3B Protein, Antibody, ELISA Kit, cDNA Clone

• GSK3B Protein

  – Human GSK3B Protein

  – Mouse GSK3B Protein

  – Rat GSK3B Protein

  – Rhesus GSK3B Protein

  – Cynomolgus GSK3B Protein

  – Canine (Dog) GSK3B Protein

  – Ferret GSK3B Protein

  – Bovine GSK3B Protein

GSK3B Protein Products

All GSK3B Products list

• GSK3B Protein

  Human GSK3B Protein, Recombinant	10044-H07B
  Mouse GSK3B Protein, Recombinant	50650-M07B

GSK3B Protein Related Products

• GSK3B Antibody

• GSK3B ELISA Kit

• GSK3B cDNA Clone

Summary of GSK3B Protein

Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules.

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