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GSK3B Protein, Antibody, ELISA Kit, cDNA Clone

GSK3B Protein, Antibody, ELISA Kit, cDNA Clone Products

With multiple advanced technology platforms and large scale capacities, Sino Biological has quickly emerging as a leader of life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. We are adding more than 800 proteins per year, of which "hot" proteins are high on the priority list, such as H1N1 antigens and antibodies that we offered.

Sino Biological Inc offers quality GSK3B Protein, Antibody, ELISA Kit, cDNA Clone Products for research .

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GSK3B Protein, Antibody, ELISA Kit, cDNA Clone

GSK3B Products

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Summary of GSK3B Protein, Antibody, ELISA Kit, cDNA Clone

Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules.

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