GRK6 (Protein|Antibody|cDNA Clone|ELISA Kit)

All GRK6 reagents are produced in house and quality controlled, including 1 GRK6 Lysate, 1 GRK6 Protein. All GRK6 reagents are ready to use.

Recombinant GRK6 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His.

GRK6 Protein (1)


GRK6 Protein, Human, Recombinant (His & GST Tag)


Expression host: Baculovirus-Insect Cells

Human GRK6 Protein 9818

GRK6 Lysate (1)

G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.