GPX7 / Glutathione peroxidase 7 Protein

GPX7 / Glutathione peroxidase 7 Products

GPX7 / Glutathione peroxidase 7 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
GPX7	Human	GPX7 / Glutathione peroxidase 7 Protein, Recombinant	12651-H02H

GPX7 / Glutathione peroxidase 7 Alternative Names

UNQ469/PRO828, CL683, FLJ14777, GPX6, GPx-7, GSHPx-7, NPGPx, glutathione peroxidase 6, non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase [Homo sapiens]

RP23-46M23.5, 3110050F08Rik, AI327032, GPX6, GPx-7, GSHPx-7 [Mus musculus]

GPX7 / Glutathione peroxidase 7 Background

GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. GPX7 is an enzyme. It has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 gene has been proposed to participate in pathways (Arachidonic acid metabolism, Glutathione metabolism) and processes (oxidation reduction, response to oxidative stress). GPX7 modulates the bone turnover after ovariectomy in rats, it does not compensate for the action of estrogen after ovariectomy in rats. It has been shown that three mAbs (GPX7, GPX22 and GPZ35) inhibit IL-6-mediated biological responses such as Ig production in a human B cell line and proliferative responses of a human Lennert's lymphoma-derived T cell line, a human myeloma cell line, and a mouse pro-B cell line-derived transfectant expressing human gp130.

GPX7 / Glutathione peroxidase 7 Related Studies

1. Rual JF, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature. 437(7062):1173-8.
2. Gregory SG, et al. (2006) The DNA sequence and biological annotation of human chromosome 1. Nature. 441(7091):315-21.
3. Lim J, et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 125(4):801-14.