GPR37

GPR37 (cathepsin Z) is an orphan receptor which belongs to the G-protein coupled receptor 1 family. G protein coupled receptors is a large protein family comprised by transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exists in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are binded and activated by light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. These ligands vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. GPR37 is expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. GPR37 may have a unique functional role in the central nervous system.

GPR37 Related Areas

Signal Transduction>>Translational Regulator>> GPR37

GPR37 Alternative Names

EDNRBL, PAELR, hET(B)R-LP, ETBR-LP-1, Parkin-associated endothelin receptor-like receptor, endothelin B receptor-like protein 1, probable G-protein coupled receptor 37 [Homo sapiens]

Pael-R, parkin-associated endothelin B-like receptor, probable G-protein coupled receptor 37 [Mus musculus]

Summaries for GPR37

Wikipedia summary for GPR37:

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.

Human GPR37 Protein General Information

 

• Protein names: Probable G-protein coupled receptor 37
  Short name=GPR37
• Sequence length: 613 AA.
• Domain: Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
• Post-translational modification: Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
• Subunit structure: Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.
• Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
• Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

General information above from UniProt

Function for GPR37 Protein

UniProtKB:

GPR37 is orphan receptor. GPR37 may have a unique functional role in the central nervous system.

Genatlas:

• GPR37 may have a unique functional role in the central nervous system
• GPR37 exhibits poor plasma membrane expression when expressed in most cell types (Dunham 2009)

Homology for human GPR37

• homolog to bombesin receptor