GP1BB Protein (CD42c Protein)

Glycoprotein Ib (platelet), beta polypeptide (Cluster of Differentiation 42c)

GP1BB Products

GP1BB Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
GP1BB/CD42c	Human	GP1BB/CD42c Protein, Recombinant	10742-H08H

GP1BB cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
GP1BB/CD42c	Human	Human GP1BB cDNA Clone / ORF Clone	HG10742-M
GP1BB/CD42c	Mouse	Mouse GP1bb cDNA Clone / ORF Clone	MG51075-G
GP1BB/CD42c	Rat	Rat GP1BB Gene cDNA Clone / ORF Clone	RG80428-G

GP1BB Alternative Names

GP1BB, CD42c

GP1BB Related Areas

Immunology>>Innate Immunity>>Coagulation>>GP1BB/CD42c

Immunology>>Cluster of Differentiation>>Other >>GP1BB/CD42c

Cardiovascular>>Coagulation>>GP1BB/CD42c

GP1BB Background

Platelet glycoprotein Ib (GPIb) complex is best known as a major platelet receptor for von Willebrand factor essential for platelet adhesion under high shear conditions found in arteries and in thrombosis. The GPIb complex is composed of GPIb alpha (Platelet glycoprotein Ib alpha chain) covalently attached to GPIb beta (Platelet glycoprotein Ib beta chain) and noncovalently complexed with GPIX and GPV. GPIb-beta, also known as GP1BB, CD42b-beta and CD42c, is single-pass type I membrane protein expressed in heart and brain, which is a critical component of the von Willebrand factor (vWF) receptor. The cysteine knot region of GPIb beta in the N terminus is critical for the conformation of GPIb beta that interacts with GPIX. The precursor of GP1BB is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. GPIb is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. GPIb alpha chain provides the vWF binding site, and GPIb beta chain contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. GP1BB is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (vWF), and mediates platelet adhesion in the arterial circulation. Defects in GP1BB are a cause of Bernard-Soulier syndrome (BSS), also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.

GP1BB Related Studies

1. Kenny D, et al. (2002) The cysteine knot of platelet glycoprotein Ib beta (GPIb beta) is critical for the interaction of GPIb beta with GPIX. Blood. 99(12): 4428-33.
2. Tang J,et al. (2004) Mutation in the leucine-rich repeat C-flanking region of platelet glycoprotein Ib beta impairs assembly of von Willebrand factor receptor. Thromb Haemost. 92(1): 75-88.
3. Vanhoorelbeke K, et al. (2007) Inhibition of platelet glycoprotein Ib and its antithrombotic potential. Curr Pharm Des. 13(26): 2684-97.
4. Clemetson KJ, et al. (2008) Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 99(3): 473-9.