Text Size:AAA

GOLM1/GP73 Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells
  • Slide 1
13066-H08H-20
13066-H08H-50
20 µg / $138
50 µg / $298
Add to Cart
Expression host: E. coli
  • Slide 1
13066-H07E-20
13066-H07E-50
20 µg / $158
50 µg / $298
Add to Cart

GOLM1/GP73 Related Areas

GOLM1/GP73 Related Pathways

GOLM1/GP73 Related Product

    GOLM1/GP73 Summary & Protein Information

    GOLM1/GP73 Background

    Gene Summary: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene.
    General information above from NCBI
    Subunit structure: Interacts with DYM.
    Subcellular location: Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
    Tissue specificity: Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
    Induction: Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.
    Post-translational: Glycosylated.
    Phosphorylation sites are present in the extracellular medium.
    Sequence similarity: Belongs to the GOLM1/CASC4 family.
    General information above from UniProt

    Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2 and GOLM1, is a protein which belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in colon, prostate, trachea and stomach. It is expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression of GOLM1 does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), GOLM1 is strongly expressed in hepatocyte-derived syncitial giant cells. GOLM1 is constitutively expressed by biliary epithelial cells but not by hepatocytes.

    GOLM1/GP73 Alternative Name

    GOLM1/GP73 Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"