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GNGT1 Protein, Antibody, ELISA Kit, cDNA Clone

GNGT1 Related Areas

GNGT1 Related Pathways

GNGT1 Related Product

    GNGT1 Summary & Protein Information

    GNGT1 Background

    Gene Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008]
    General information above from NCBI
    Subunit structure: G proteins are composed of 3 units, alpha, beta and gamma.
    Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
    Tissue specificity: Retinal rod outer segment.
    Sequence similarity: Belongs to the G protein gamma family.C
    General information above from UniProt

    GNGT1 is a subunit of of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GNGT1 Alternative Name

    GNG1,guanine nucleotide-binding protein G(T) subunit gamma-T1,transducin gamma chain, [human]
    guanine nucleotide binding protein (G protein),G(y)1,gamma 1 subunit,Gng1,guanine nucleotide-binding protein G(T) subunit gamma-T1,transducin gamma chain, [mouse]

    GNGT1 Related Studies

  • Tao L, et al. (1993) Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. Exp Eye Res. 56 (4): 497-507.
  • Yan K, et al. (1996) Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. J Biol Chem. 271 (12): 7141-6.
  • Gaudet R, et al. (1999) A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Mol Cell. 3 (5): 649-60.
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