All GNGT1 reagents are produced in house and quality controlled, including 2 GNGT1 Antibody, 15 GNGT1 Gene, 1 GNGT1 Protein, 1 GNGT1 qPCR. All GNGT1 reagents are ready to use.
Recombinant GNGT1 proteins are expressed by E. coli with fusion tags as N-His.
GNGT1antibodies are validated with different applications, which are ELISA.
GNGT1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each GNGT1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
GNGT1 is a subunit of of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.