GMFB

GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. It contains 1 ADF-H domain and is phosphorylated after phorbol ester stimulation. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.

GMFB Alternative Names

GMF, GMF-beta, glia maturation factor beta [Homo sapiens]

3110001H22Rik, 3110001O16Rik, AI851627, C79176, D14Ertd630e, GMF-beta, glia maturation factor beta [Mus musculus]

Summaries for GMFB

Wikipedia summary for GMFB:

Glia maturation factor is a nerve growth factor implicated in nervous system development, angiogenesis and immune function.
The structures of mouse glia maturation factors beta and gamma, solved by both crystallography and NMR, reveal similarities and critical differences with ADF-H (actin depolymerization factor homology) domains and suggest new means of experimentally addressing the function of this protein family.

Human GMFB Protein General Information

 

• Protein names: Glia maturation factor beta
  Short name=GMF-beta
  Short name=GMFB
• Sequence length: 142 AA.
• Sequence similarities: Belongs to the actin-binding proteins ADF family. GMF subfamily.
  Contains 1 ADF-H domain.
• Post-translational modification: Phosphorylated; stimulated by phorbol ester.

General information above from UniProt

Function for GMFB Protein

UniProtKB:

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

Genatlas:

• GMFB causes differentiation of brain cells, stimulation of neural regeneration and inhibition of proliferation of tumor cells
• GMFB is protein kinase ERK1/ERK2 inhitor and p38 MAP kinase activator
• GMFB is intracellular regulator of signal transduction pathways

Homology for human GMFB

• homolog to murine Gmfb
• homolog to GMFG