All GM2A reagents are produced in house and quality controlled, including 3 GM2A Antibody, 39 GM2A Gene, 1 GM2A Lysate, 1 GM2A Protein, 1 GM2A qPCR. All GM2A reagents are ready to use.
Recombinant GM2A proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.
GM2Aantibodies are validated with different applications, which are ELISA, IHC-P, ICC/IF, IF.
GM2AcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each GM2A of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB), also known as Tay-Sachs disease AB variant.