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Product Catalog
> GM-CSF Protein & Antibody (GMCSF, CSF2 Protein) GM-CSF Protein & Antibody (GMCSF, CSF2 Protein)
Granulocyte-Macrophage Colony-Stimulating Factor (Colony Stimulating Factor 2)
GM-CSF Products
GM-CSF Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| GM-CSF/CSF2 | Human | GM-CSF/CSF2/Fc Protein, Recombinant |
10015-H01H |
| GM-CSF/CSF2 | Human | GM-CSF / CSF2 Protein, Recombinant | 10015-H07H |
GM-CSF Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human GM-CSF/CSF2 | WB, ELISA | GM-CSF / CSF2 Antibody | 10015-MM06 |
GM-CSF ELISA Kits
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human GM-CSF/CSF2 | ELISA | GM-CSF / CSF2 ELISA Pair Set, Human ELISA Pair Set | SEK10015 |
GM-CSF cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| GM-CSF/CSF2 | Human | GM-CSF/CSF2 cDNA Clone(NM_000758.2) | HG10015-M |
| GM-CSF/CSF2 | Rat | GM-CSF/CSF2 cDNA Clone | RG80020-M |
| GM-CSF/CSF2 | Mouse | CSF2 cDNA Clone / ORF Clone | MG51048-G |
GM-CSF Related Areas
Cancer>>Growth Factor & Receptor>>CSF & Receptor>>GM-CSF/CSF2
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>GM-CSF/CSF2
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family Signaling Related Molecules>>GM-CSF/CSF2
GM-CSF Alternative Names
GM-CSF, CSF2, GMCSF, MGC131935, MGC138897 [Homo sapiens]
Gm-CSf, Csf2, Csfgm, MGC151255, MGC151257, MGI-IGM [Mus musculus]
GM-CSF Background
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.
GM-CSF Related Studies
- Robertson SA. (2007) GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-98.
- Waller EK. (2007) The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12 Suppl 2: 22-6.
- Clive KS, et al. (2010) Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 9(5): 519-25.
GM-CSF related areas, pathways, and other information
