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GM-CSF Protein & Antibody (GMCSF, CSF2 Protein)

Granulocyte-Macrophage Colony-Stimulating Factor (Colony Stimulating Factor 2)

GM-CSF Products

GM-CSF Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
GM-CSF/CSF2 Human GM-CSF/CSF2/Fc Protein, Recombinant 10015-H01H
GM-CSF/CSF2 Human GM-CSF / CSF2 Protein, Recombinant 10015-H07H
GM-CSF/CSF2 Mouse Mouse GM-CSF / CSF2 Protein, His Tag 51048-M07H
GM-CSF/CSF2 Mouse Mouse GM-CSF / CSF2 Protein 51048-M01H
GM-CSF/CSF2 Rat Rat GM-CSF / CSF2 Protein, His Tag 80020-R07H
GM-CSF/CSF2 Rat Rat GM-CSF / CSF2 Protein 80020-R01H

  10015-H01H:  Immobilized CD131 at 10 μg/mL (100 µl/well) can bind recombinant human GM-CSF / Fc with a linear range of 0.032–4 µg/ml. Measured by its binding ability in a functional ELISA.

GM-CSF Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human GM-CSF/CSF2 WB, ELISA GM-CSF / CSF2 Antibody 10015-MM06

GM-CSF ELISA Kits

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human GM-CSF/CSF2 ELISA GM-CSF / CSF2 ELISA Pair Set, Human ELISA Pair Set SEK10015

GM-CSF Cell Lysates

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
GM-CSF/CSF2 Human Human GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 10015-H07HL
GM-CSF/CSF2 Human Human GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 10015-H01HL
GM-CSF/CSF2 Mouse Mouse GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 51048-M01HL
GM-CSF/CSF2 Mouse Mouse GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 51048-M07HL
GM-CSF/CSF2 Rhesus Rat GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 80020-R07HL
GM-CSF/CSF2 Rhesus Rat GM-CSF / CSF2 Human Cells Transfected Lysate (positive control) (denatured) 80020-R01HL

GM-CSF cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
GM-CSF/CSF2 Human GM-CSF/CSF2 cDNA Clone(NM_000758.2) HG10015-M
GM-CSF/CSF2 Human Human GM-CSF ORF Expression Clone, Myc-tagged (Codon Optimized) HG10015-M-M
GM-CSF/CSF2 Human Human GM-CSF ORF Expression Clone, untagged HG10015-M-N
GM-CSF/CSF2 Rat GM-CSF/CSF2 cDNA Clone RG80020-M
GM-CSF/CSF2 Mouse CSF2 cDNA Clone / ORF Clone MG51048-G

GM-CSF Related Areas

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>GM-CSF/CSF2

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>GM-CSF/CSF2

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family Signaling Related Molecules>>GM-CSF/CSF2

GM-CSF Alternative Names

GM-CSF, CSF2, GMCSF, MGC131935, MGC138897 [Homo sapiens]

Gm-CSf, Csf2, Csfgm, MGC151255, MGC151257, MGI-IGM [Mus musculus]

GM-CSF Background

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.

GM-CSF Related Studies

  1. Robertson SA. (2007) GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-98.
  2. Waller EK. (2007) The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12 Suppl 2: 22-6.
  3. Clive KS, et al. (2010) Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 9(5): 519-25.

 

 

GM-CSF related areas, pathways, and other information

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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