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GLO1 / Glyoxalase 1 Antibody, Rabbit MAb
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GLO1 / Glyoxalase 1 Antibody, Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50364-R043  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

GLO1 / Glyoxalase 1 Antibody Datasheet

  Order or Inquire for GLO1 / Glyoxalase 1 Antibody product Quality antibodies Antibody production services
  Detection limit is 0.00975 ng/well in ELISA
 

GLO1 / Glyoxalase 1 Antibody Product Information

Immunogen :

Recombinant Mouse GLO1 / Glyoxalase 1 protein (Catalog#50364-M07E)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID :

043

Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GLO1 / Glyoxalase 1 (rM GLO1 / Glyoxalase 1; Catalog#50364-M07E; NP_079650.3; Ala 2-Ile 184).

GLO1 / Glyoxalase 1 Antibody Usage Guide

Specificity :

Mouse GLO1 / Glyoxalase 1

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse GLO1. The detection limit for Mouse GLO1 is approximately 0.00975 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

GLO1 / Glyoxalase 1 Antibody Related Products & Topics

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GLO1 / Glyoxalase 1 Antibody Background

Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. GLO1 / Glyoxalase I has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. GLO1 / Glyoxalase I catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. GLO1 / Glyoxalase I exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties. GLO1 upregulation may play a functional role in glycolytic adaptations of cancer cells.

References

  1. Wu, YY. et al., 2008,Prog Neuropsychopharmacol Biol Psychiatry. 32 (7): 1740-4.
  2. Williams,R. et al., 2009, PLoS One. 4 (3): e4649.
  3. Antognelli,C. et al., 2009, BMC Cancer. 9: 115.
  4. Bair,W.B. et al., 2010, Melanoma Res. 20 (2): 85-96.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"