This gene encodes a member of the TNF-receptor superfamily. GITR has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this GITR gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
OMIM-Description for GITR / TNFRSF18
Members of the tumor necrosis factor (TNF; 191160) and TNF receptor (TNFR) superfamilies, such as GITR, regulate diverse biologic functions, including cell proliferation, differentiation, and survival. For further background information on the TNF and TNFR superfamilies, see TNFRSF1A (191190).
.zh=GITR / TNFRSF18
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) or glucocorticoid-induced TNFR-related protein (GITR) is a protein that in humans is encoded by the TNFRSF18 gene.
GITR is receptor for TNFSF18. GITR seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR mediates NF-kappa-B activation via the TRAF2/NIK pathway.
GITR is involved in regulation of T cell receptor-mediated cell death
GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death