- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Tumor necrosis factor receptor superfamily, member 18 Protein Datasheet
GITR / TNFRSF18 Protein Price Inquiry ( Available Sizes )
GITR / TNFRSF18 Protein Product Information
A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
GITR / TNFRSF18 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
GITR / TNFRSF18 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu 25|
The recombinant rat TNFRSF18/Fc is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
GITR / TNFRSF18 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
GITR / TNFRSF18 Protein Related Products & Topics
GITR / TNFRSF18 Protein Description
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
- Won B. et al., 1999, J Biol Chem. 274 (10): 6056-61.
- Nocentini G. et al., 1997, Proc Natl Acad Sci. 94 (12): 6216-21.
- Kim YS. et al., 2007, Oncol Rep. 18 (5): 1189-94.
GITR (TNFRSF18) related areas, pathways, and other information
|Tumor Necrosis Factor (TNF) Family & Receptor|