GFRA3 Protein & Antibody

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3

GFRA3 Products

GFRA3 Protein, Recombinant

Molecule	Species	Description	Cat. No
GFRA3	Human	GFRA3/Fc Protein, Recombinant	10213-H03H
GFRA3	Human	GFRA3 Protein, Recombinant	10213-H08H
GFRA3	Mouse	GFRA3 / GFR-alpha-3 Protein, Recombinant	50901-M02H

  10213-H03H:  Measured by its ability to bind mouse ARTN in a functional Elisa.

GFRA3 Antibody

Molecule	Application	Description	Cat. No
Human GFRA3	WB, ELISA	GFRA3 Antibody, Rabbit PAb	10213-RP01
Human GFRA3	WB, ELISA	GFRA3 Antibody, Rabbit PAb (Antigen Affinity Purified)	10213-RP02
Human GFRA3	WB, ELISA	GFRA3 Antibody	10213-R118

GFRA3 cDNA Clone

Molecule	Species	Description	Cat. No
GFRA3	Human	Homo sapiens GFRA3 DNA ORF Clone(NM_001496.3)	HG10213-M
GFRA3	Mouse	Mouse GFRA3 cDNA Clone / ORF Clone	MG50901-G

GFRA3 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>GDNF Family>>GFRA3

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>GDNF Family>>GFRA3

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>GFRA3

GFRA3 Alternative Names

GFRA3, GDNFR-alpha-3, GFR-alpha-3 [Homo sapiens]

Gfra3, Y15110, GDNFR-alpha-3, GFR-alpha-3 [Mus musculus]

GFRA3 Related Products

Protein Products

Molecule	Species	Description
GFRA1	Human	GFRA1 Protein, Recombinant
GFRA1	Mouse	GFRA1 Protein, Recombinant
GFRA1	Rat	GFRA1 Protein, Recombinant
GFRA2	Human	GFRA2 Protein, Recombinant
GFRA2	Mouse	GFRA2 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit PAb
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
GFRA1	Human	Homo sapiens GFRA1 transcript variant 2 cDNA Clone(NM_145793.2)
GFRA1	Mouse	Mus musculus GFRA1 cDNA Clone
GFRA1	Rat	Rattus norvegicus GFRA1 cDNA Clone
GFRA2	Human	Homo sapiens GFRA2 cDNA Clone(NM_001495.4)
GFRA2	Mouse	Mus musculus GFRA2 cDNA Clone

GFRA3 Background

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.

GFRA3 Related Studies

1. Widenfalk J, et al. (2000) Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell Tissue Res. 299(3): 409-15.
2. Li J, et al. (2009) Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS Lett. 583(15): 2479-85.
3. Yang C, et al. (2006) Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues. J Mol Histol. 37(1-2): 69-77.